Co₉Se₈ Nanoplates as a New Theranostic Platform for Photoacoustic/Magnetic Resonance Dual‐Modal‐Imaging‐Guided Chemo‐Photothermal Combination Therapy

Abstract

A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)‐Co9 Se8 nanoplates. These PAA‐Co9 Se8 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance imaging (MRI) dual‐modal imaging. Moreover, the PAA‐Co9 Se8‐DOX shows pH‐responsive chemotherapy and enables the combination of photothermal therapy and chemotherapy to receive superior antitumor efficacy. This work promises further exploration of 2D nanoplatforms for theranostic applications.

A Multifunctional Nanocrystalline CaF2:Tm,Yb@mSiO2 System for Dual‐Triggered and Optically Monitored Doxorubicin Delivery

“…As shown in Figure 2c, with the increased particle concentration from 0 to 120 µg mL −1 , the relative cell viability with respect to the blank control retained over 90% viability after incubation for 24 and 48 h. An analogous scenario was observed when examined using MCF-7 cells; all concentrations of UCNPs remained at a high relative cell viability (Figure S3, Supporting Information), reflecting that the PAA-modified UCNPs possess low cell cytotoxicity and good cytocompatibility under certain culture time and concentration range, which is in agreement with the findings reported elsewhere. [10,22] One notable fact is that different silica surface modification protocols may induce cytotoxicity or varied biological effects. [20] …”

Recent advances of semiconducting polymer nanoparticles in in vivo molecular imaging

“…Despite the promise of PA imaging in biology and medicine, full utilization of its potential heavily relies on the development of efficient PA agents. By now, small-molecule organic dyes,[89, 90] fluorescent proteins,[91, 92] metallic nanoparticles,[93–99] carbon nanotubes,[100, 101] two-dimensional graphene analogues [102–105] and porphysomes [106–108] have been studied as exogenous contrast agents. Development of imaging agents has already contributed to facilitate the application PA imaging in monitoring anatomic and physiological changes in diseases, and continues to be active in molecular imaging.…”

Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications

“…Transition metal chalcogenides (TMC)-based nanomaterials, such as copper sulfide (CuS), tungsten sulfide (WS 2 ), molybdenum sulfide (MoS 2 ) and so on, due to energy band transitions, are a class of semiconductor nanocrystals with strong NIR absorption 62-69. Among them, CuS nanoparticles, due to their good photothermal effect and low cost, have been extensively studied for PAI 70-73.…”