Co‐production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma

Abstract

Vascular endothelial-cadherin produced by endothelial cells could be regulated by iNOS-producing cells in periapical granulomas and might play a pivotal role in vascular permeability.

Immunohistochemical Comparison of iNOS in Pericoronal Dental Follicles and Periapical Inflammatory Lesions

“…the obtained results in this study are compatible with previously performed studies about iNOS-IR in PILs (10,11,22,23,24). One of the first studies revealing iNOS-IR presence in periapical tissues was performed by takeichi et al on radicular cysts.…”

“…Ca 2+ / calmodulin-independent type ii noS, also called macrophage noS or inoS isoform, is responsible for no production in development of Pils and is the most investigated type (2,10,11,22,23,24). However, it is not clear whether iNOS expression in PG and Rc groups differs between each other (11,10,23,24). iNOS may have an pivotal role in activation and proliferation of odontogenic epithelial components in DFs like in Pils progression.…”

Inducible Nitric Oxide Synthase Immunoreactivity in Denture Induced Fibrous Inflammatory Hyperplasia and Healthy Oral Mucosa: An Immunohistochemical Study

“…The important effects of iNOS produced NO in pulpa (15), periapical tissue (19,21,37,38,39) and periodontal inflammatory lesions (1,20,24) have been shown. The iNOS based proliferative potential in epithelial tissues on periapical inflammatory lesions has been emphasized (37).…”

“…In the following research it has been reported that NO, being an important intercellular and extracellular messenger molecule, has both homeostatic functions like vasodilatation, neurotransmission, inhibition of platelet adhesion and aggregation, and also host defense functions against infectious agents such as bacteria, fungi and parasites, and tumor cells (29). Although NO is important in host defense and homeostasis, it is also regarded as harmful and has been implicated in the pathogenesis of a wide variety of inflammatory conditions (1,15,19,21,35,37,38,39). NO is synthesized by a group of isoenzymes collectively named NO synthase (NOS).…”

Receptor for advanced glycation end products (RAGE)-expressing endothelial cells co-express AGE and S100 in human periapical granulomas

“…[22][23][24] The interaction between RAGE and inducible nitric oxide by endothelial cells has also been studied, 25 and a possible role of these inflammatory mediators in tissue injury has been suggested. However, the interaction of RAGE with AGE or S100 in periapical periodontitis has not been assessed.…”