Co‐occurrence of autoantibodies in healthy blood donors

Prüßmann, Jasper N.; Prüßmann, Wiebke; Recke, Andreas; Rentzsch, Kristin; Juhl, David; Henschler, Reinhard; Müller, Susen; Lamprecht, Peter; Schmidt, Enno; Csernok, Elena; Görg, Siegfried; Stöcker, W.; Zillikens, Detlef; Ibrahim, Saleh M.; Ludwig, Ralf J.

doi:10.1111/exd.12445

Cited by 31 publications

(33 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17,18 The data in healthy controls, using the IF (immunofluorescence) method, have shown ANA positivity in a relatively high proportion of individuals: >10% at 1:80 dilution. 19,20 However, although the reported frequency of positive serum ANA in the general population was high, the frequency we observed in the NCWS was evidently even higher. We also found ANA-positive sera at a low dilution (median, 1:80) and in the absence of specific signs or symptoms of overt ADs, in particular systemic lupus erythematosus.…”

Section: Discussioncontrasting

confidence: 55%

High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies

Carroccio

D’Alcamo

Cavataio³

et al. 2015

Gastroenterology

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 55%

High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies

Carroccio

D’Alcamo

Cavataio³

et al. 2015

Gastroenterology

View full text Add to dashboard Cite

“…The complete absence of anti-BP180 IgG auto-antibodies in healthy para is in line with previous reports on the frequency of anti-BP180 IgG auto-antibodies in healthy blood donors and in healthy pregnant women (14,15), indicating that anti-BP180 NC16A IgG auto-antibodies do not emerge in healthy pregnancies. However, in some patients with PG, low titres of anti-BP180 auto-antibodies were detectable by ELISA, but mostly remained too low to reach the assay's cut-off value (7).…”

Section: Discussionsupporting

confidence: 92%

Value of BIOCHIP Technology in the Serological Diagnosis of Pemphigoid Gestationis

Sadik¹,

Pas²,

Bohlmann³

et al. 2017

Acta Derm Venerol

View full text Add to dashboard Cite

“…Hence, the association of EBA with CD and UC seems likely, but needs to be determined prospectively. Interestingly, ANAs were detected in 20.0% of EBA patients, whereas ANA prevalence in healthy controls ranges between 8 and 24% [61–65]. Thus, ANA reactivity seems increased in EBA patients.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients

Iwata

Vorobyev

Koga

et al. 2018

Orphanet J Rare Dis

Self Cite

View full text Add to dashboard Cite

BackgroundEpidermolysis bullosa acquisita (EBA) is an orphan autoimmune disease. Several clinical phenotypes have been described, but subepidermal blistering is characteristic of all variants. Limited data on clinical and immunopathological characteristics and treatment outcomes in EBA are available. To fill this gap, we collected this information from EBA cases, meeting current diagnostic criteria, published between 1971 and 2016.ResultsWe identified 1159 EBA cases. This number must be, however, interpreted with caution, as it is not possible to check for multiple reporting. The analysis of all cases indicated that EBA affects all age groups (median: 50 years, range: 1 to 94 years) at an equal gender distribution. Non-mechanobullous (non-MB) forms of EBA were observed in 55% of patients, whereas the mechanobullous variant (MB-EBA) or a combination of both variants was described in 38 or 7% of patients, respectively. Type VII collagen (COL7)-specific autoantibodies were primarily of the IgG isotype, but anti-COL7 IgA, IgM and IgE were also documented. Comparison of the 2 clinical EBA types showed a higher frequency of IgA deposits in non-MB EBA as opposed to MB EBA. Mucous membrane involvement was observed in 23% of patients, and 4.4% of cases were associated with other chronic inflammatory diseases. Of note, IgA deposits were more frequently observed in cases with mucous membrane involvement. Our analysis indicated that EBA is difficult to treat and that the choice of treatment varies widely. Chi square was applied to identify medications associated with complete remission (CR). Considering all EBA cases, intravenous immunoglobulin (IVIG, p = 0.0047) and rituximab (p = 0.0114) were associated with CR. Subgroup analysis demonstrated that no treatment was associated with CR for non-MB EBA, while IVIG (p = 0.003) was associated with CR in MB EBA.ConclusionsWithin the limitations of the study, we here document the clinical and immunopathological characteristics and treatment outcomes in a large cohort of EBA patients. The observed associations of single drugs with treatment outcome may serve as a guide to develop clinical trials.Electronic supplementary materialThe online version of this article (10.1186/s13023-018-0896-1) contains supplementary material, which is available to authorized users.

show abstract

Co‐occurrence of autoantibodies in healthy blood donors

Cited by 31 publications

References 17 publications

High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies

High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies

Value of BIOCHIP Technology in the Serological Diagnosis of Pemphigoid Gestationis

Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients

Contact Info

Product

Resources

About