Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coating

Abstract

We have incorporated bisphosphonates and antibiotics simultaneously into a biomimetic hydroxyapatite implant coating aiming to use the interaction between drug-molecules and hydroxyapatite to enable local release of the two different substances to obtain a dual biological effect. A sustained release over for 43 h of antibiotics (cephalothin) was achieved without negative interference from the presence of the bisphosphonate (clodronate) which, in turn, successfully bonded to the coating surface. To our knowledge, this is the first study that indicates the possibility to simultaneously incorporate both antibiotics and bisphosphonates to an implant coating, a strategy that is believed to improve implant stability and reduce implant-related infections.

Dexrazoxane shows cytoprotective effects in zoledronic acid-treated human cells in vitro and in the rabbit tibia model in vivo

“…The idea of local drug administration in BRONJ prevention is simple and starts with local antibiotics as discussed earlier (Ferlito et al, 2011;Forsgren et al, 2011). Another option is the replacement of geranylgeraniol as the production is blocked by the nitrogencontaining bisphosphonates (nBP) (Marcuzzi et al, 2011;Ziebart et al, 2011).…”

Osteogenicity of titanium implants coated with calcium phosphate or collagen type-I in osteoporotic rats

“…First, a CaP coated implant surface can provide a physicochemical matrix suitable for the deposition of new bone by osteoblasts [13,48]. Therefore, a CaP coating can improve osteogenic cell attachment and reaction to the implant surface as a result of protein adsorption onto the coated surface [18,49]. In addition, release of Ca 2þ and PO 4 3À ions from the coated implants has been speculated to regulate the initiation of cellular signals that enhance osteoblast differentiation [50].…”

Bioceramic Coatings for Medical Implants

“…In fact, bone is composed of HA nanocrystals in a collagen matrix. Therefore, instead of simple surface adsorption, co-precipitation of biological active molecules during the formation of the coating is gaining significant attention [68,69]. The most promising methods are those that produce CaP coatings at room temperature from aqueous solutions.…”