Co-expression of vascular endothelial growth factor C (VEGF-C) and c-erbB2 in human breast carcinoma

Hoar, Fiona; Chaudhri, S.; Wadley, M; Stonelake, Paul S.

doi:10.1016/s0959-8049(03)00382-4

Cited by 33 publications

(13 citation statements)

References 26 publications

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“…C-C ligand chemokines have again often been implicated in cancer progression [85][86][87][88][89][90][91][92][93], and increased expression of CCL28 has been reported in colon cancer [86]. The final two factors, hepatocyte growth factor and vascular endothelial growth factor, have long been reported to be involved in breast cancer progression [59][60][61][94][95][96][97][98] and to regulate Src kinase activity [68][69][70][71][72][73][74]99]. We are interested in determining the role of these five factors, secreted by bonederived cells, on breast cancer cell migration and Src kinase activity.…”

Section: Discussionmentioning

confidence: 99%

Role of Src in breast cancer cell migration and invasion in a breast cell/bone-derived cell microenvironment

Pohorelic

Singh

Parkin

et al. 2011

Breast Cancer Res Treat

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The preferential metastasis of breast cancer cells to bone comprises a complex set of events including homing and preferential growth, which may require unique factors produced by bone or other cells in the immediate microenvironment. In this study, an in vitro co-culture system composed of bone mesenchymal stem cells and breast cancer cell lines is used to examine the role of Src kinase on breast cancer cell migration and invasion in the presence of bone-derived cells. This research shows that Src kinase activity in breast cancer cell lines with either high or low levels of endogenous Src activity is increased by bone-derived cell-conditioned medium but not HS68 fibroblast-conditioned medium. Breast cancer cells exhibit enhanced migration in co-culture with bone-derived cells but not HS68 fibroblasts or no co-cultured cells. Inhibition of Src kinase activity using the inhibitors PP2 or saracatinib or using siRNA abrogates the preferential migration of the breast cancer cell lines in response to bone-derived cells. Inhibition of Src activity with saracatinib does not have any significant effect on breast cancer cell invasion in the presence of bone-derived cells. Factors are identified that are produced preferentially by bone-derived cells over HS68 cells that may impact breast cancer cell behavior. This research implicates Src kinase as an important effector of bone-derived cell signals on breast cancer cell migration.

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Section: Discussionmentioning

confidence: 99%

Role of Src in breast cancer cell migration and invasion in a breast cell/bone-derived cell microenvironment

Pohorelic

Singh

Parkin

et al. 2011

Breast Cancer Res Treat

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“…The secreted VEGF-C concentration was increased significantly under hypoxia in MCF7 and A549 tumour cells compared with the normoxic condition (33). The expression of HIF-1a correlates with VEGF-C expression in breast cancer and oral squamous cell carcinoma (34,35). In this present study, we demonstrated that the transcription level of CNTN-1 correlated with that of HIF-1a, suggesting a possible role for CNTN-1 under hypoxia.…”

Section: Overexpression Of Cntn-1 In Esccsmentioning

confidence: 95%

Contactin-1 (CNTN-1) Overexpression is Correlated with Advanced Clinical Stage and Lymph Node Metastasis in Oesophageal Squamous Cell Carcinomas

Liu

Chen

et al. 2012

Japanese Journal of Clinical Oncology

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Objective: Oesophageal squamous cell carcinoma is one of the deadliest malignancies worldwide. Contactin-1, a neural adhesion molecule, is implicated in tumour invasion and metastasis. The purpose of this study was to investigate the expression of CNTN-1 in normal and cancerous oesophageal tissue, and the potential relevance to clinicopathological features. Methods: Thirty normal oesophageal tissue samples and 82 primary oesophageal squamous cell carcinoma tissue samples were included in this study. The expression levels of CNTN-1, VEGF-C and HIF-1a messenger RNA were determined using reverse transcriptase -polymerase chain reaction and quantitative real-time polymerase chain reaction. The expression of the CNTN-1 protein was measured using immunohistochemistry. Results: The expression of CNTN-1 messenger RNA was significantly increased in the tumour tissue compared with the normal oesophageal tissue (P ¼ 0.001). The oesophageal squamous cell carcinoma tissue consistently showed higher CNTN-1 protein levels. The CNTN-1 expression correlated with the oesophageal squamous cell carcinoma stage (P ¼ 0.006), lymph node metastasis (P ¼ 0.018) and lymphatic invasion (P ¼ 0.035). The messenger RNA level of CNTN-1 correlated significantly with those of VEGF-C and HIF-1a. Conclusions: The expression of CNTN-1 is upregulated in the oesophageal squamous cell carcinoma tissue and related to stage, lymph node metastasis and lymphatic invasion. Thus, CNTN-1 may be involved in the progression and pathogenesis of oesophageal squamous cell carcinoma.

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“…Eleven studies (53-63) described the relationship between VEGF-C expression and the regional lymph node status in breast cancer. Although three studies on breast cancer (53)(54)(55) demonstrated a significant correlation between the VEGF-C expression and the lymph node status, eight studies failed to find a significant correlation between the VEGF-C expression and the lymph node status in breast cancers (56)(57)(58)(59)(60)(61)(62)(63). The reason why the VEGF-C expression did not correlate directly with the lymph node status, whereas significantly positive correlations were observed between the VEGF-C expression and LVD and between LVD and the lymph node status in the present study, is that the VEGF-C expression is inversely correlated with the tumor size, which is positively correlated with the lymph node status.…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

The Akt expression correlates with the VEGF-A and -C expression as well as the microvessel and lymphatic vessel density in breast cancer

et al. 2010

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Co-expression of vascular endothelial growth factor C (VEGF-C) and c-erbB2 in human breast carcinoma

Cited by 33 publications

References 26 publications

Role of Src in breast cancer cell migration and invasion in a breast cell/bone-derived cell microenvironment

Role of Src in breast cancer cell migration and invasion in a breast cell/bone-derived cell microenvironment

Contactin-1 (CNTN-1) Overexpression is Correlated with Advanced Clinical Stage and Lymph Node Metastasis in Oesophageal Squamous Cell Carcinomas

The Akt expression correlates with the VEGF-A and -C expression as well as the microvessel and lymphatic vessel density in breast cancer

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