Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation

Pouponneau, Pierre; Leroux, Jean‐Christophe; Soulez, Gilles; Gaboury, Louis; Martel, Sylvain

doi:10.1016/j.biomaterials.2010.12.059

Cited by 219 publications

(144 citation statements)

References 34 publications

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“…[1][2][3][4][5] Yin and Yates reported that drug-entrapped biodegradable microcapsules, with sustained drug release, were prepared by spraying a suspension of hollow poly(DL-lactide) particles in procaine hydrochloride aqueous solution into plasticizing solvents. 6 A further report by Zvonar et al described use of a self-microemulsifying system to fabricate Ca-pectinate microcapsules to improve the release and permeability of furosemide.…”

Section: Introductionmentioning

confidence: 99%

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Chen¹,

Wang²,

Wang³

et al. 2012

IJN

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Background:The aim of this study was to improve the drug loading, encapsulation efficiency, and sustained-release properties of supercritical CO 2 -based drug-loaded polymer carriers via a process of suspension-enhanced dispersion by supercritical CO 2 (SpEDS), which is an advanced version of solution-enhanced dispersion by supercritical CO 2 (SEDS). Methods: Methotrexate nanoparticles were successfully microencapsulated into poly (L-lactide)-poly(ethylene glycol)-poly(L-lactide) (PLLA-PEG-PLLA) by SpEDS. Methotrexate nanoparticles were first prepared by SEDS, then suspended in PLLA-PEG-PLLA solution, and finally microencapsulated into PLLA-PEG-PLLA via SpEDS, where an "injector" was utilized in the suspension delivery system. Results: After microencapsulation, the composite methotrexate (MTX)-PLLA-PEG-PLLA microspheres obtained had a mean particle size of 545 nm, drug loading of 13.7%, and an encapsulation efficiency of 39.2%. After an initial burst release, with around 65% of the total methotrexate being released in the first 3 hours, the MTX-PLLA-PEG-PLLA microspheres released methotrexate in a sustained manner, with 85% of the total methotrexate dose released within 23 hours and nearly 100% within 144 hours. Conclusion: Compared with a parallel study of the coprecipitation process, microencapsulation using SpEDS offered greater potential to manufacture drug-loaded polymer microspheres for a drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Chen¹,

Wang²,

Wang³

et al. 2012

IJN

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“…The MRN approach is more suitable for micrometer-sized soft magnetic microrobots. However, it should be noticed that experimental results have shown that therapeutic particles (known as TMMC), 50-60 µm diameter were navigated in arteries (rabbit models) and that MRN was done with gradient coils (capable of 450 mT/m with inner diameter suitable for limbs or head interventions) installed in the tunnel of clinical MRI scanners [31].…”

Section: Microrobotic Surgical Planning Demonstrationmentioning

confidence: 99%

Simulation and Planning of a Magnetically Actuated Microrobot Navigating in the Arteries

Belharet¹,

Folio²,

Ferreira³

2013

IEEE Trans. Biomed. Eng.

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Abstract-This work presents a preoperative microrobotic surgical simulation and planning application. The main contribution is to support computer-aided minimally invasive surgery (MIS) procedure using untethered microrobots that have to navigate within the arterial networks. We first propose a fast interactive application (with endovascular tissues) able to simulate the blood flow and microrobot interaction. Secondly, we also propose a microrobotic surgical planning framework, based on the anisotropic Fast Marching Method (FMM), that provides a feasible pathway robust to biomedical navigation constraints. We demonstrate the framework performance in a case study of the treatment of peripheral arterial diseases (PAD).Index Terms-Microrobotics, minimally invasive surgery, blood flow simulation, anisotropic path planning.

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“…MNPs have been attracting much attention because of their prospective biomedical applications, either as contrast agents for magnetic resonance imaging (MRI) [1], heating mediators for hyperthermia [2], introcellular cell labeling and tracking [3], or as drug/gene delivery carriers [4]. Several materials including iron oxide (γ-Fe 2 O 3 or Fe 3 O 4 ), cobalt, nickel and manganese ferrites, metals and metal alloys such as Fe and FePt, have been developed [5].…”

Section: Overview Of Magnetic Nanoparticlesmentioning

confidence: 99%

In vitro biological effects of magnetic nanoparticles

Chen

2012

Chin. Sci. Bull.

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Magnetic nanoparticles (MNPs) have great potential for a wide use in various biomedical applications due to their unusual properties. It is critical for many applications that the biological effects of nanoparticles are studied in depth. To date, many disparate results can be found in the literature regarding nanoparticle-biological factors interactions. This review highlights recent developments in this field with particular focuses on in vitro MNPs-cell interactions. The effect of MNPs properties on cellular uptake and cytotoxicity evaluation of MNPs were discussed. Some employed methods are also included. Moreover, nanoparticle-cell interactions are mediated by the presence of proteins absorbed from biological fluids on the nanoparticle. Many questions remain on the effect of nanoparticle surface (in addition to nanoparticle size) on protein adsorption. We review papers related to this point too. The current development of magnetic nanoparticles (MNPs) requires a better understanding of its biological effects. A great deal of work has been conducted to study MNPsbiological factors interactions. Many researchers bend themselves to in vitro cell-based assessment. In this work, the current knowledge of how the in vitro cultured cells can interact with the exposed colloid MNPs is discussed as well as the effect of nanoparticle size and surface properties on cell responses. The specific cell line selected for in vitro assay is intended to model a response or phenomenon likely observed or sensitized by particles in vivo. Here, the frequent lack of consistency or predictability between in vitro models and in vivo observations, which is because of the different biological conditions particles exposed to and the changed cell phenotype against primary cell types, is out of our consideration. As we have known, cell monocultures as measured by in vitro assays rarely react in such isolated pathways in native tissues comprosed of multiple, dynamically communicative cell types that produce non-linear and correlated response to foreign materials.Adsorption of proteins onto the nanoparticle surface happens immediately after particles come in contact with a biological fluid, and it is the proteins associate with nanoparticles, leading to a protein "corona" which defines the biological identity of the particle. Here, we also try to review some current work on associated protein "corona" when nanoparticles were incubated in biological medium.

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Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation

Cited by 219 publications

References 34 publications

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Simulation and Planning of a Magnetically Actuated Microrobot Navigating in the Arteries

In vitro biological effects of magnetic nanoparticles

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