Co-encapsulation of Egg-White-Derived Peptides (EWDP) and Curcumin within the Polysaccharide-Based Amphiphilic Nanoparticles for Promising Oral Bioavailability Enhancement: Role of EWDP

Abstract

The comprehensive utilization of food-derived nutraceuticals with different polarities has been extremely restricted by their poor bioavailability and coexistence in a single system. This study aimed to fabricate a self-assembly of amphiphilic nanoparticles (NPs) for the hydrophilic EWDP and hydrophobic curcumin based on the carboxymethyl chitosan (CMCS) shell and γ-cyclodextrin (γ-CD) core. Notably, EWDP could cooperate with CMCS to yield superior colloidal properties with an excellent curcumin aqueous solubility and co-encapsulation capacity (>10%) for the NPs (pH 2.0−7.0). This phenomenon was mainly ascribed to the additional hydrogen-bonding network and hydrophobic interaction introduced by EWDP. Besides, the overall antioxidant activity, bioaccessibility, gastrointestinal stability, and Caco-2 cell absorption properties were significantly improved in the presence of EWDP (>20% increase). Therefore, EWDP could function as both a potential affinity agent and a nutrition enhancer to expand the co-delivery applications for diverse nutraceuticals with promising oral bioavailability enhancement in food and pharmaceutical areas.

Novel γ-cyclodextrin-based metal–organic frameworks for the effective encapsulation of oregano essential oil and controlled release

“…25 Other researchers have found similar results with peak excursions and intensity changes, demonstrating that there exist interactions between the wall material and the encapsulated compound. 40,43–45 Interestingly, other concentrations of ICs displayed a similar variation trend in the FT-IR spectra as those produced by γ-CD-MOF-OEO 4.…”

“…16,38 In the spectrum of γ-CD-MOF-OEO 4, the peaks in γ-CD-MOF at 2891.7 cm −1 and 1416.9 cm −1 (C–H bending vibration) shifted to 2918.7 cm −1 and 1408.7 cm −1 , separately, thus indicating a slight alteration after encapsulation, which may be due to the presence of modification or chemical interaction forces between γ-CD-MOF and OEO. 39–42 The peak at 877 cm −1 belonging to γ-CD-MOF disappeared in γ-CD-MOF-OEO 4, which could be owing to the interaction between γ-CD-MOF and OEO. 25 Other researchers have found similar results with peak excursions and intensity changes, demonstrating that there exist interactions between the wall material and the encapsulated compound.…”

A Comprehensive Review of Self-Assembled Food Protein-Derived Multicomponent Peptides: From Forming Mechanism and Structural Diversity to Applications

“…(c) The stability, redispersibility, and bioactivity enhancement of the precursor template-induced FPDMPs self-assembly system. Reproduced with permission from our previous studies. , Copyright 2022 Elsevier and American Chemical Society. (d) Precursor template-induced FPDMPs self-assembly to construct novel delivery carriers for nutraceutical delivery and enhance their functional activity.…”

“…Reproduced with permission from our previous study. 78 Copyright 2022 American Chemical Society. (b) The protein−polysaccharides complexes induce egg white-derived peptides (EWDPs).…”

Acid-Resistant Mesoporous Metal–Organic Frameworks as Carriers for Targeted Hypoglycemic Peptide Delivery: Peptide Encapsulation, Release, and Bioactivity

“…Different materials show different encapsulation capabilities for peptides. For example, self-assembled nanoparticles (NPs) based on the carboxymethyl chitosan shell and the γ-cyclodextrin (γ-CD) core could encapsulate egg white-derived peptides (EWDPs) and curcumin, and the encapsulation capacity was about 10% of the NPs at pH 2.0–7.0 . A pH-triggered self-unpacking capsule encapsulating zwitterionic hydrogel-coated MOF NPs was developed to protect exendin against gastrointestinal degradation and promote penetration across the intestinal mucosa .…”