PLoS ONE volume 9, issue 5, Pe98349 2014 DOI: 10.1371/journal.pone.0098349 View full text
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Marina A. Afanasyeva, Liudmila V. Britanova, Kirill V. Korneev, Nikita A. Mitkin, Anna A. Kuchmiy, Dmitry V. Kuprash

Abstract: Clusterin is a multifunctional protein that participates in tissue remodeling, apoptosis, lipid transport, complement-mediated cell lysis and serves as an extracellular chaperone. The role of clusterin in cancer and neurodegeneration has been extensively studied, however little is known about its functions in the immune system. Using expression profiling we found that clusterin mRNA is considerably down-regulated in mouse spleen stroma upon knock-out of lymphotoxin β receptor which plays pivotal role in second…

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