1983
DOI: 10.1055/s-2007-1021976 View full text |Buy / Rent full text
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Abstract: In 28 male Wistar rats a standardized lung incision was closed by running suture and in half of the animals by additional application of fibrin adhesive. The animals were sacrificed 30 minutes and 5 days postoperatively. A significantly higher tolerance to increased inflation pressure was found in the fibrin-treated group. Ten patients undergoing pulmonary resection had conventional closure of parenchymatous lesions with additional fibrin gluing. Under positive air way pressure ventilation the sealing effect p… Show more

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“…It leads to prolonged chest tube drainage time that is associated with pain and immobilization and consequently increases the patient's risk of the development of empyema and other serious complications [1]. Fibrin sealant has been widely used since the early 1980s as an effective tool to seal pulmonary air leakage in lung surgery [1][2][3][4]. Thoracic surgeons, however, have often found that fibrin sealant used for pulmonary parenchymal defects could not effectively seal air leakages.…”
Section: Introductionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…It leads to prolonged chest tube drainage time that is associated with pain and immobilization and consequently increases the patient's risk of the development of empyema and other serious complications [1]. Fibrin sealant has been widely used since the early 1980s as an effective tool to seal pulmonary air leakage in lung surgery [1][2][3][4]. Thoracic surgeons, however, have often found that fibrin sealant used for pulmonary parenchymal defects could not effectively seal air leakages.…”
Section: Introductionmentioning
“…[15][16][17] Türk et al reported that fibrin glue sealing of a suture line significantly increased the pressure tolerance in comparison with conventional lung sutures, when investigated intraoperatively. 16 On the other hand, a number of thoracic surgeons have found that for pulmonary parenchymal defects, the use of fibrin glue without suturing fails to prevent air leakage during surgery and tends to lead to postoperative recurrence of the leakage.…”
Section: Discussionmentioning
“…Os trabalhos de Thetter (21) e Turk et al (22) foram os primeiros a atestarem uma melhor efetividade no controle do escape aéreo das suturas pulmonares com a utilização da cola. Thetter descreveu o uso de cola durante a toracotomia, tanto isolada como em combinação com pleurodese abrasiva, como método de alcançar pleurodese em pacientes portadores de pneumotórax espontâneo.…”
Section: Discussionunclassified
“…O mesmo autor não observou diferenças significativas no tempo de permanência dos drenos pleurais em pacientes submetidos à ressecção pulmonar que tiveram o parênquima revestido por cola de fibrina, quando comparados a um grupo de controle histórico que não recebeu aplicação do selante. Os trabalhos de Thurk et al (22) foram baseados em estudos experimentais em ratos. Após submeterem dois grupos de ratos a secção traumática do parênquima pulmonar, observaram que a cobertura da lesão com cola de fibrina conferia maior resistência à pressão na via aé-rea quando comparada ao grupo sem revestimento por selante.…”
Section: Discussionunclassified