Clostridium cadaveris Osteomyelitis: an Unusual Pathogen which Highlights the Importance of Deep Tissue Sampling in Chronic Osteomyelitis

Corrigan, Ruth; Lomas-Cabeza, Jose; Stubbs, David; McNally, Martin

doi:10.7150/jbji.43801

Cited by 6 publications

(6 citation statements)

References 28 publications

(36 reference statements)

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“… Clostridium cadaveris , first isolated in 1899 ( 1 ), is a rod-shaped, Gram-positive anaerobic bacterium typically present in the human gastrointestinal tract ( 2 , 3 ). Reported pathogenic associations include equine idiopathic colitis ( 4 ), a human abscess ( 5 ), bacteremia ( 6 ), and chronic osteomyelitis ( 7 ). Here, we report the isolation of C. cadaveris IFB3C5, a strain cultivated from the necrotic tissue of a colorectal cancer tumor.…”

Section: Announcementmentioning

confidence: 99%

Complete Genome Sequence of Clostridium cadaveris IFB3C5, Isolated from a Human Colonic Adenocarcinoma

McGlinchey

Zepeda-Rivera

Stepanovica

et al. 2022

Microbiol Resour Announc

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Section: Announcementmentioning

confidence: 99%

Complete Genome Sequence of Clostridium cadaveris IFB3C5, Isolated from a Human Colonic Adenocarcinoma

McGlinchey

Zepeda-Rivera

Stepanovica

et al. 2022

Microbiol Resour Announc

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“…More than 30 cases of clostridial joint infection have been described in the past [9] and Corrigan et al described the only known case of chronic Clostridium cadaveris tibial infection, in a 32-year-old immunocompetent person [14]. Even though both patients were immunocompetent and the entry point for infection is direct trauma with the ground, our case differs on several parameters as the duration of the infection, the infection site, and the total duration of antibiotic therapy chosen.…”

Section: Discussionmentioning

confidence: 76%

Trauma-Induced Clostridium cadaveris Septic Arthritis of the Knee in an Immunocompetent Young Patient: A Case Report

Lemonnier,

Payen,

Curado

2024

Am J Case Rep

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Objective:Rare disease Background:Clostridium cadaveris is a motile, anaerobic, gram-positive, spore-forming bacillus usually found in soil. However, rare cases of opportunistic infections have been documented in immunosuppressed individuals. This report details the case of an immunocompetent young patient who developed septic arthritis of the knee after a traumatic injury involving a rusty nail. The aim of this paper is to provide a comprehensive literature review, shed light on the potential occurrence of Clostridium cadaveris septic arthritis, and explore its management. Case Report:A young patient with no medical history presented a traumatic inoculation leading to septic arthritis on a native knee by Clostridium cadaveris. The patient underwent 2 surgical debridements after an initial bad evolution under probabilistic antibiotic therapy. Bacteriological long-growing cultures and antibiotic testing were employed to guide antibiotic therapy selection. The patient had a favorable clinical outcome with no residual knee complications, with laboratory results showed good evolution. A review of the literature showed that Clostridium cadaveris septic arthritis in immunocompetent patients is very rare. The management and subsequent results emphasize the potential impact of the initial emergency room treatment on patient outcomes, especially concerning seemingly benign traumas. Conclusions:This case report highlights the necessity of rapid diagnosis of the cause of septic arthritis, particularly in children, to prevent joint and tissue damage, and the rare diagnosis of knee arthritis with Clostridium cadaveris. This report expands understanding of osteoarticular infections and enhances the need for rapid diagnosis and early treatment, when managing cases with atypical presentations.

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“…Limited case reports have been published describing C. cadaveris as the causative organism in spontaneous bacterial peritonitis, chronic osteomyelitis, and bacteremia stemming from a gastrointestinal source. [3][4][5] Only eight case reports have been published to date describing C. cadaveris bacteremia with several of these cases stemming from a gastrointestinal source. 6 Bacteremia with any clostridial species is exceedingly rare, accounting for 0.5-2% of all positive blood cultures.…”

Section: Discussionmentioning

confidence: 99%

Clostridium Cadaveris Bacteremia in an Immunocompromised Host

Saito,

Wu,

Kwoh

2024

Journal of Brown Hospital Medicine

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Clostridial bacteremia is an exceedingly rare clinical entity that can cause significant morbidity and mortality. Immunocompromised patients with insult to the gastrointestinal mucosa are especially prone to the development of clostridial sepsis based on limited existing literature. Here we report a case of a 65-year-old male nursing home resident with incompletely treated colorectal adenocarcinoma who was admitted for sepsis. He was found to have polymicrobial bacteremia with Escherichia coli and Clostridium cadaveris. He was successfully treated with intravenous piperacillin/tazobactam followed by an oral regimen of amoxicillin/clavulanic acid.

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Clostridium cadaveris Osteomyelitis: an Unusual Pathogen which Highlights the Importance of Deep Tissue Sampling in Chronic Osteomyelitis

Cited by 6 publications

References 28 publications

Complete Genome Sequence of Clostridium cadaveris IFB3C5, Isolated from a Human Colonic Adenocarcinoma

Complete Genome Sequence of Clostridium cadaveris IFB3C5, Isolated from a Human Colonic Adenocarcinoma

Trauma-Induced Clostridium cadaveris Septic Arthritis of the Knee in an Immunocompetent Young Patient: A Case Report

Clostridium Cadaveris Bacteremia in an Immunocompromised Host

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