The compact design of a 500 kV quadruple-circuit transmission line can effectively reduce the line corridor area, but the height of the tower also increases, increasing the probability of suffering a lightning strike. The 500 kV quadruple-circuit transmission lines carry more energy, and because of this, lightning strikes that cause power line trips are more likely to result in large-scale power outages. Therefore, it is necessary to make an accurate assessment of the lightning performance of 500 kV quadruple-circuit transmission lines. First, simulated lightning-striking experiments were carried out on a scaled 500 kV quadruple-circuit transmission line in the laboratory, where transient voltages and currents were measured. Second, a numerical model was established with the Finite-Difference Time Domain (FDTD) method, which was then verified with the experimental results. Third, lightning surge responses of a 500 kV quadruplecircuit transmission line under near-real facility conditions are estimated with the verified FDTD model. In the simulations, influencing factors, such as the rise time of injecting current, the velocity of return-stroke current and the terrains, were taken into consideration, but not in previous lightning surge analysis with the Electromagnetic Transients Program (EMTP). Results show that insulator voltages on the same tower crossarm are nearly identical, although the length of the cross-arm is large enough. Furthermore, it is found that the rise time and the lightning current velocity have great effects on the lightning surge response, and the terrains are less impactful but not negligible. Therefore, these factors should be considered carefully where higher accuracy lightning protection design is necessary.INDEX TERMS FDTD, lightning protection, lightning surge response, quadruple-circuit tower, reducedscale experiment.