Close Vaginal Margins as a Prognostic Factor after Radical Hysterectomy

Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix

“…This is in line with the rate of close (≤5 mm) vaginal margin of approximately 4.2% in Estape et al study (Estape et al, 1998) and the rate of surgical margin involvement of 8.3% in Chittithaworn et al study (Chittithaworn et al, 2007) in similar study population. It should be noted that two-third of those who had positive vaginal surgical margin had no other highrisk factors such as pelvic node metastasis and parametrial metastasis.…”

Patient age, tumor appearance and tumor size are risk factors for early recurrence of cervical cancer

“…The mortality rate in patients with early recurrence is even higher (14). Previous studies identified several risk factors, such as tumor size and lymph node metastasis, which are associated with the recurrence of cervical cancer (7)(8)(9)(10). Consistently, in our present study, we identified tumor size as an independent risk factor associated with early recurrence of cervical cancer.…”

“…Furthermore, the risk factors contributing to early recurrence (<2 years) have not been investigated, although recurrence and metastasis of cervical cancer contribute to a poor prognosis. Other molecular analyses have demonstrated that altered expression of different genes predicts early recurrence of cervical cancer (7)(8)(9)(10), but these may not be superior to routine clinicopathological parameters (7)(8)(9)(10). Thus, in this study, we aimed to perform a retrospective analysis of 284 cervical cancer patients with disease recurrence in order to determine the association of their clinicopathological parameters with early cervical cancer recurrence.…”

“…Patients with recurrent cervical cancer exhibit a very high mortality, despite several currently available treatment options, although central-local recurrences, most likely due to a better clinical response to chemoradiation therapy, have a better overall survival rate compared to lateral-pelvic recurrences (45.4 vs. 18.2%, respectively) (4)(5)(6). Previous studies have demonstrated that lymph node metastasis, parametrial and surgical margin involvement, tumor size and deep stromal invasion, but not histological type or grade, significantly affect cervical cancer recurrence (7)(8)(9)(10). However, the risk factors that are considered to contribute to cervical cancer recurrence are not universally accepted or duplicated in other study populations.…”

Prediction of Recurrence in Patients with Cervical Cancer Using MARS and Classification

“…These include tumor size, lymphovascular space involvement, depth of tumor invasion, lymph node metastasis, and parametrial involvement. Prognostic models combining these factors were also devised [17], [18]. These factors are interrelated, but analyses using these factors do not reflect the true prognoses.…”