2003
DOI: 10.1182/blood-2003-04-1150
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Abstract: Eosinophilia is common in myeloproliferative disorders (MPDs) with abnormalities of chromosome band 5q31-33, including those that present with t(1; 5)(q23;q33). With the development of rational drug therapy, characterization of the molecular targets for these translocations could guide treatment and affect patient survival. We cloned the t(1; 5)(q23;q33) and showed that it fuses platelet-derived growth factor receptor beta (PDGFRB) to the coiled-coil domains of a novel partner protein, myomegalin. Using two-co… Show more

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Cited by 113 publications
(74 citation statements)
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“…In addition to FGFR1, several other TKs (Figure 1) are involved in MPDs and other partners of TKs have been described. These partners are ninein (NIN) in t(5;14) with NIN-PDGFRB fusion, 28 TRIP11/ CEV14/GMAP210 in t(5;14) with CEV14-PDGFRB fusion, 29 H4 in t(5;10) with H4-PDGFRB fusion, 30 rabaptin 5 in t(5;17) with RABEP1-PDGFRB fusion, 31 HCMOGT1 in t(5;17) with HCMOGT1-PDGFRB fusion, 32 PDE4DIP/myomegalin in t(1;5) with PDE4DIP-PDGFRB fusion, 33 an uncharacterised protein in t(5;14), 34 TP53BP1 in t(5;15) with TP53BP1-PDGFRB fusion 35 and FIP1L1 in del(4q) with FIP1L1-PDGFRA fusion. 36,37 NIN is a bona fide centrosomal protein.…”
Section: How Many Mpds Are Centrosomal Diseases?mentioning
confidence: 99%
“…In addition to FGFR1, several other TKs (Figure 1) are involved in MPDs and other partners of TKs have been described. These partners are ninein (NIN) in t(5;14) with NIN-PDGFRB fusion, 28 TRIP11/ CEV14/GMAP210 in t(5;14) with CEV14-PDGFRB fusion, 29 H4 in t(5;10) with H4-PDGFRB fusion, 30 rabaptin 5 in t(5;17) with RABEP1-PDGFRB fusion, 31 HCMOGT1 in t(5;17) with HCMOGT1-PDGFRB fusion, 32 PDE4DIP/myomegalin in t(1;5) with PDE4DIP-PDGFRB fusion, 33 an uncharacterised protein in t(5;14), 34 TP53BP1 in t(5;15) with TP53BP1-PDGFRB fusion 35 and FIP1L1 in del(4q) with FIP1L1-PDGFRA fusion. 36,37 NIN is a bona fide centrosomal protein.…”
Section: How Many Mpds Are Centrosomal Diseases?mentioning
confidence: 99%
“…Since then, a large variety of fusion partners for PDGFRB have been described, most of which, however, are single case reports (Table 4). [23][24][25][26][27][28][29][30][31][32][33][34][35][36] Despite the rare frequency (o1%) of PDGFRB rearrangements in cytogenetically defined cases of chronic myelomonocytic leukemia and other myeloid neoplasms (for example, atypical CML, juvenile myelomonocytic leukemia, chronic basophilic leukemia, myelodysplastic syndrome/MPN overlap), their recognition is essential given the exquisite sensitivity of such cases to imatinib.…”
Section: Terminology and Classificationmentioning
confidence: 99%
“…BAC DNAs were isolated and hybridized to the patient's slides as we described previously. 10 Using this strategy, we found der(9q) deletion in 7 (14.5%) of the 48 CML patients analyzed. In two samples, the deletion extended as far centromeric as to include both miRNA loci ( Figure 1b); there were no instances of deletion of miR-219-2 or 199b in samples with an otherwise intact der(9q).…”
mentioning
confidence: 99%