Zhihua Xie, Eric J. Vallender, Naichen Yu, Shelli L. Kirstein, Hong Yang, Mary E. Bahn, Susan V. Westmoreland, Gregory M. Miller
Several recent studies report an association between trace amine-associated receptor 6 (TAAR6) and susceptibility to schizophrenia and bipolar affective disorder (BPAD) in humans. However, endogenous TAAR6 agonists and the receptor signaling profile and brain distribution remain unclear. Here, we clone TAAR6 from the rhesus monkey and use transfected cells to investigate whether this receptor interacts with brain monoamines and a psychostimulant drug to trigger cAMP signaling or ERK phosphorylation, while inv…
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