J. Neurosci. Res. volume 86, issue 15, P3435-3446 2008 DOI: 10.1002/jnr.21783 View full text
Zhihua Xie, Eric J. Vallender, Naichen Yu, Shelli L. Kirstein, Hong Yang, Mary E. Bahn, Susan V. Westmoreland, Gregory M. Miller

Abstract: Several recent studies report an association between trace amine-associated receptor 6 (TAAR6) and susceptibility to schizophrenia and bipolar affective disorder (BPAD) in humans. However, endogenous TAAR6 agonists and the receptor signaling profile and brain distribution remain unclear. Here, we clone TAAR6 from the rhesus monkey and use transfected cells to investigate whether this receptor interacts with brain monoamines and a psychostimulant drug to trigger cAMP signaling or ERK phosphorylation, while inv…

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