Cloning and Genomic Characterization of Felis domesticus Papillomavirus Type 1

Tachezy, Ruth; Duson, Griet; Rector, Annabel; Jenson, A. Bennett; Sundberg, John P.; Ranst, Marc Van

doi:10.1006/viro.2002.1566

Cited by 75 publications

(83 citation statements)

References 19 publications

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“…However, a second non-coding-region was not found in either the BPV-Type I or II genome, although it has been identified in certain artiodactyla and carnivore PVs; e.g. European elk PV (EEPV), deer PV (DPV), reindeer PV (RPV), canine oral PV and Felis domesticus PV (Groff & Lancaster, 1985; Delius et al, 1994: Tachezy et al, 2002Rector et al, 2005).…”

Section: Journal Of General Virologymentioning

confidence: 99%

Genomic and phylogenetic analysis of two novel bovine papillomaviruses, BPV-9 and BPV-10

Hatama

Nobumoto

Kanno

2008

Journal of General Virology

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Eight bovine papillomavirus (BPV) types, BPV-1-8, have been classified, based on genome nucleotide sequence similarities, in the genera Deltapapillomavirus (BPV-1 and -2), Epsilonpapillomavirus (BPV-5 and -8), Xipapillomavirus (BPV-3, -4 and -6) and an unassigned genus (BPV-7). We report here the complete genome sequence of two new BPV types isolated from separate epithelial squamous papilloma lesions on cattle teats. The genomes are 7303 and 7399 bp in length, respectively, and both have genetic organization and consensus motifs typical of papillomaviruses. A neighbour-joining phylogenetic tree revealed that both viruses cluster with BPV-3, -4 and -6. Nucleotide sequence identities of the BPV L1 major capsid protein of these two new BPVs with BPV-3, their closest relative, are 74.2 and 71.2 %, respectively. These results suggest that both viruses are new BPV types in the genus Xipapillomavirus, and they are designated BPV-9 and BPV-10.Bovine papillomavirus (BPV) is an aetiological agent associated with several forms of cutaneous and mucosal papillomas (Campo, 2002). Six different types of BPVs have been distinguished on the basis of DNA sequence relatedness. Each BPV is associated with type-specific lesions (Jarrett et al., 1984): BPV-1 and BPV-2 are classified in the genus Deltapapillomavirus and infect the epithelium and dermis, giving rise to fibropapillomas; BPV-3, BPV-4 and BPV-6 are classified in the genus Xipapillomavirus and are strictly epitheliotropic, inducing true epithelial papillomas, and BPV-5 is classified in the genus Epsilonpapillomavirus and infects the epithelium and dermis, inducing both fibropapillomas and true epithelial papillomas of the skin (Bloch et al., 1994;Campo 2002;de Villiers et al., 2004). Recently, 16 putative new BPV types were partially cloned and sequenced from healthy skin swabs (Antonsson & Hansson, 2002;Ogawa et al., 2004). Two of the BPVs were characterized further by cloning and sequencing their complete genomes. Phylogenetic analysis showed that both viruses were new BPV types: one was designated BPV-7 and classified as a member of a new papillomavirus (PV) genus, and the other was designated BPV-8 and classified as a member of the genus Epsilonpapillomavirus Tomita et al., 2007). However, the tumorigenic potential of these two new BPV types and the other 14 putative new BPV types has not been elucidated. In a previous report, we identified two putative new BPV types, designated BPV-Type I and BPV-Type II, which may have caused an outbreak of bovine teat papillomatosis in Japan (Maeda et al., 2007). BPV-Type I and II were identified by PCR amplification of a 590 bp DNA fragment within the BPV genome L1 major capsid protein gene (GenBank accession no. AB253592 for type I; no. AB253595 for type II). However, the remaining BPV-Type I and II genome sequences have not been reported. In this study, the complete genome sequences of BPV-Type I and II were determined. These sequencing and phylogenetic analysis results showed that BPV-Type I and II are new BPV types (designated...

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Section: Journal Of General Virologymentioning

confidence: 99%

Genomic and phylogenetic analysis of two novel bovine papillomaviruses, BPV-9 and BPV-10

Hatama

Nobumoto

Kanno

2008

Journal of General Virology

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“…1 Currently, 4 PV types have been fully classified from domestic cats, including Felis catus PV-1 (FcaPV-1) from a cutaneous viral plaque, FcaPV-2 and FcaPV-3 from cutaneous bowenoid in situ carcinomas, and FcaPV-4 from a sample of gingivitis. 2,10 PV infection is also thought to cause feline sarcoids (fibropapillomas), although current evidence suggests that these lesions are caused by a bovine PV. The PVs of domestic cats have been referred to as Felis domesticus PVs.…”

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Oral Papillomas Associated With Felis catus Papillomavirus Type 1 in 2 Domestic Cats

Munday

Fairley²,

Mills³

et al. 2015

Vet Pathol

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Multiple small sessile raised lesions were detected on the ventral surface of the tongue in two 13-year-old domestic cats. The lesions were incidental in both cats. Lesions from both cats appeared histologically as well-demarcated foci of markedly thickened folded epithelium that formed keratin-filled shallow cuplike structures. Large keratinocytes that contained a swollen nucleus surrounded by a clear cytoplasmic halo (koilocytes) were common, suggesting a diagnosis of a papillomavirus-induced papillomas, and papillomavirus antigen was demonstrated by immunohistochemistry. The papillomas exhibited diffuse intense cytoplasmic and nuclear immunoreactivity against cyclin-dependent kinase inhibitor 2A protein (also known as p16 or INK4a protein). Felis catus papillomavirus type 1 DNA sequences were amplified from both papillomas. The papillomas resolved in 1 cat within 3 months of diagnosis, while the papillomas were still visible 4 months after diagnosis in the other cat. This is the first evidence that these papillomas are caused by F. catus papillomavirus type 1.Keywords felis catus papillomavirus, papilloma, oral cavity, wart, cat Papillomaviruses (PVs) have been detected in all species that have been studied, with most species infected by multiple PV types. Most PV infections do not result in the development of clinically detectable lesions; however, depending on both PV type and host factors, PVs can cause a range of hyperplastic and neoplastic lesions.1 Currently, 4 PV types have been fully classified from domestic cats, including Felis catus PV-1 (FcaPV-1) from a cutaneous viral plaque, FcaPV-2 and FcaPV-3 from cutaneous bowenoid in situ carcinomas, and FcaPV-4 from a sample of gingivitis.2,10 PV infection is also thought to cause feline sarcoids (fibropapillomas), although current evidence suggests that these lesions are caused by a bovine PV. The PVs of domestic cats have been referred to as Felis domesticus PVs.In contrast to those of other species, PV-induced papillomas (warts) in domestic cats are rare, with only 2 oral papillomas and 2 cutaneous papillomas previously reported.2,9 While a cutaneous papilloma was found to contain DNA sequences from a human PV type, the PV type present in oral papillomas in domestic cats has not been previously investigated. Herein, 2 cats with oral papillomas are described. Papillomas in both cats developed on the ventral surface of the tongue and contained FcaPV-1 PV DNA sequences.Cat No. 1 was a 13-year-old neutered male domestic shorthair cat that was observed during a routine dental procedure to have numerous <3-mm diameter pale raised lesions on the ventral surface of the tongue (Fig. 1). Similar lesions on the ventral surface of the tongue were also observed in a 13-year-old male neutered Abyssinian cat (cat No. 2) during surgical drainage of a ranula. Samples were taken from both cats and submitted for histology.Lesions from both cats consisted of well-demarcated foci of markedly thickened folded epithelium that projected as thick tongues into the underly...

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“…COPV is the largest of all known PV genomes, and contains a unique second non-coding region (NCR2) between the early and late protein region. Recently, a second carnivore PV genome, containing a similar NCR2, was isolated from a cutaneous lesion of a Persian cat (Felis domesticus PV type 1, FdPV-1) (Tachezy et al, 2002a). COPV and FdPV-1 share a high degree of sequence similarity, and belong to the genus Lambda PV.…”

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“…2), which was constructed in MEGA version 2.1 (Kumar et al, 2001), clusters the PVs in the different genera described in the new PV classification (de Villiers et al, 2004), and the additional Rho and Sigma genera (Rector et al, 2004;Rector et al, 2005). In this tree, PlPV-1 clusters with COPV and FdPV-1 in the genus Lambda.With a mutation rate of 0?73-1?2610 28 nucleotide substitutions per base per year (Van Ranst et al, 1995;Tachezy et al, 2002a), PVs are very stable viruses that evolve through slow accumulation of point mutations, and recombination 57 (54) 58 (57) 49 (44) 39 (32) 38 (24) L1 68 (71) 63 (67) 58 (57) 52 (49) 55 (47) NA, Insufficient similarity between the two sequences to allow unambiguous alignment.http://vir.sgmjournals.org 2031Procyon lotor papillomavirus (PlPV-1) between different PV types has never been documented. The observed global distribution of a broad genetic diversity of PVs, together with the viral species specificity, the stability of their genomes, and the requirement for close contact for PV transmission, has led to the hypothesis that PVs are ancient viruses that have co-evolved and cospeciated with their host species during vertebrate evolution (Van Ranst et al, 1995).…”

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Isolation and cloning of the raccoon (Procyon lotor) papillomavirus type 1 by using degenerate papillomavirus-specific primers

Rector

Doorslaer

Bertelsen

et al. 2005

Journal of General Virology

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Partial sequences of a novel papillomavirus were amplified from a cutaneous lesion biopsy of a raccoon (Procyon lotor), by using PCR with degenerate papillomavirus-specific primers. The Procyon lotor papillomavirus type 1 (PlPV-1) DNA was amplified with long template PCR in two overlapping fragments, together encompassing the entire genome, and the complete PlPV-1 genomic sequence was determined. The PlPV-1 genome consists of 8170 bp, and contains the typical papillomaviral open reading frames, encoding five early proteins and two late capsid proteins. Besides the classical non-coding region (NCR1) between the end of L1 and the start of E6, PlPV-1 contains an additional non-coding region (NCR2) of 1065 bp between the early and late protein region, which has previously also been described for the canine oral papillomavirus (COPV) and the Felis domesticus papillomavirus (FdPV-1). Phylogenetic analysis places PlPV-1 together with COPV and FdPV-1 in a monophyletic branch which encompasses the Lambda papillomavirus genus.The Papillomaviridae are a large family of species-specific viruses that cause proliferations of the stratified squamous epithelium of the skin or the mucosa in a wide variety of host species (Sundberg et al., 2001). Over 90 human papillomavirus (HPV) types have been completely sequenced (de Villiers et al., 2004), and these cause a wide spectrum of genotype-specific lesions (Van Ranst et al., 1992). Only a limited number of non-human PV genotypes have been fully genetically characterized so far (Sundberg et al., 1997(Sundberg et al., , 2001de Villiers et al., 2004), but these cover a broad range of host species, and it is likely that most mammalian and avian species carry their own set of species-specific PV types.Papillomatosis has been documented in a number of carnivores, mainly Canidae and Felidae (Sundberg, 1987;Sundberg et al., 2000). In 1994, the genomic sequence of the canine oral PV (COPV), associated with oropharyngeal papillomatosis in dogs, coyotes and wolves, was characterized (Delius et al., 1994). COPV is the largest of all known PV genomes, and contains a unique second non-coding region (NCR2) between the early and late protein region. Recently, a second carnivore PV genome, containing a similar NCR2, was isolated from a cutaneous lesion of a Persian cat (Felis domesticus PV type 1, FdPV-1) (Tachezy et al., 2002a). COPV and FdPV-1 share a high degree of sequence similarity, and belong to the genus Lambda PV.Papillomavirus infection has been reported in raccoons (Procyon lotor), small carnivores that are widely distributed throughout North America. In one study, 2 of 53 wild trapped raccoons showed proliferative skin lesions that stained positive for PV group-specific antigens (Hamir et al., 1995). Since dogs and raccoons both belong to the suborder Caniformia of the Carnivora, investigation of the relationship between the canine COPV and the raccoon PV would be interesting to test the hypothesis that PVs have co-evolved with their host species.We report here the complete genomic seq...

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Cloning and Genomic Characterization of Felis domesticus Papillomavirus Type 1

Cited by 75 publications

References 19 publications

Genomic and phylogenetic analysis of two novel bovine papillomaviruses, BPV-9 and BPV-10

Genomic and phylogenetic analysis of two novel bovine papillomaviruses, BPV-9 and BPV-10

Oral Papillomas Associated With Felis catus Papillomavirus Type 1 in 2 Domestic Cats

Isolation and cloning of the raccoon (Procyon lotor) papillomavirus type 1 by using degenerate papillomavirus-specific primers

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