Cloning and expression of a zebrafish 5-HT2C receptor gene

The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling

“…Consistent with HPA/I axis activation, total cortisol levels, as measured by ELISA at 30hpf, were increased in serotonin- and fluoxetine-treated embryos ( Figure 5C, Figure S6C ). Hypothalamus-associated 5-HTR2C (Schneider et al, 2012), reported to induce the HPA axis (Heisler et al, 2007) and shown here to impact HSPCs ( Figure S1B,C, Figure S3C,D ) despite an absence in the VDA ( Figure S1A ), was examined to corroborate the mechanism of serotonergic regulation. Indeed, exposure to 5-HTR2C agonist MK212 increased expression levels of HPA/I axis genes ( Figure S6D ).…”

Kisspeptin1 modulates odorant‐evoked fear response via two serotonin receptor subtypes (5‐HT1A and 5‐HT2) in zebrafish

“…), and although localization has only been carried out in 2 dpf larval zebrafish, the presence of the receptor has been noted in various brain regions (Schneider et al . ), with its role suggested in the control of escape swimming behaviour in larvae (Douglass et al . ).…”

“…In the zebrafish, olfactory projections combine into a circuitry in the telencephalic region and the hypothalamus, similar to that of the mammalian amygdala (Gayoso et al 2011(Gayoso et al , 2012. The 5-HT 1A -like, 5-HT 1B and 5-HT 2 receptors are also noted in homologous regions in the zebrafish brain (Norton et al 2008;Schneider et al 2012). Communication between neuropeptides and 5-HT receptors have been shown to be necessary in fear and anxiety outcomes (Davis 1992;Graeff et al 1996;Tanaka et al 2013).…”

Abuse potential of methylenedioxymethamphetamine (MDMA) and its derivatives in zebrafish: role of serotonin 5HT2-type receptors

“…The antagonistic effect found with ritanserin likely agrees with the characteristic activation of serotonin 5-HT 2 receptors in brain (for reference, see Araújo et al 2015). Notably, serotonin 5-HT 2C subtype receptor has been recently sequenced and cloned from zebrafish brain showing to be highly homologous to human and mouse sequences (Schneider et al 2012). …”

“…As serotonin 5-HT 2A receptor agonists have typically been referred to Bhallucinogens^and some of them (LSD, mescaline) tested also in zebrafish (Neelkantan et al 2013), we investigated the role of serotonin 5HT 2 -like receptors, previously identified in zebrafish (Schneider et al 2012), on the reward and the appearance of trance-like behavior .…”