Cloning and characterization of a second member of the mouse mdr gene family.

Abstract

The mammalian mdr gene family comprises a small number of closely related genes. Previously, we have shown that one member, mdrl, has the capacity to convey multidrug resistance to drug-sensitive recipient cells in a gene transfer protocol. However, the functional characteristics of other members of this gene family have not been examined. In this report, we characterize a second member of the mdr gene family which we designated mdr2. We determined the nucleotide sequence corresponding to the complete coding …