Clonazepam release from core-shell type nanoparticles in vitro

Synthesis and Self-Assembly of Well-Defined Block Copolypeptides via Controlled NCA Polymerization

“…Block copolymers make up a large class of micelle forming molecules [68,70,71], and include some that contain polypeptide segments, which can be enzymatically degraded to natural metabolites and possess ordered conformations not found in conventional polymers. Numerous "rod-coil" micelles have been prepared using α-helical hydrophobic polypeptides conjugated to hydrophilic polyethylene glycol (PEG) segments, such as PEG-b-PBLG [72,73] and PEG-b-PBLA [74]. β-strand polypeptide segments have also been used to facilitate interchain interactions and increase micelle stability [75].…”

All-trans retinoic acid-incorporated nanoparticles of deoxycholic acid-conjugated dextran for treatment of CT26 colorectal carcinoma cells

“…1,[5][6][7] Nanoaggregates or polymeric micelles are appropriate vehicles for incorporation of hydrophobic drugs, due to their self-association characteristics and hydrophobic interaction in the aqueous environment. In particular, small nanoaggregates or nanoparticles have such advantages as long blood circulation of drugs, avoiding unwanted side effects of anticancer drugs, ease of administration, and solubilization of hydrophobic drugs.…”

“…18 From these points of view, nanoparticles formed by a self-aggregation process can solve these problems. [5][6][7]20,21,24 Nanoparticles or polymeric micelles are known to be effective in extending blood circulation times of anticancer drugs, decreasing side effects of drugs, and suppression of tumor cell growth. 3,6,24 As shown in Figure 1, Figure 2, and Table 1, we prepared RA-incorporated DexDA nanoparticles for antitumor drug delivery.…”

“…[1][2][3][4] In particular, since nanoaggregates have small particle sizes of less than 1000 nm, they are frequently considered for targeted delivery of anticancer drugs to the site of action. [1][2][3][4][5][6][7] They have such advantages as solubilization of hydrophobic drugs, reduction of total dose of drug administered, prevention of undesirable side effects, and non-necessity of surgical removal after use. [1][2][3][4][5][6][7] In particular, nanoparticles based on amphiphilic macromolecules have an inherent structure such that the hydrophobic domain of amphiphilic macromolecules composes the inner core of the nanoparticles for drug incorporation and the hydrophilic domain composes the surrounding region of the nanoparticles.…”

‘Surfactant-free’ stable nanoparticles from biodegradable and amphiphilic poly(ε-caprolactone)-grafted dextran copolymers

“…More recently, poly-(lactide-co-glycolide) nanoparticles were prepared by using poly(ethylene glycol)-based block copolymers as substitutes for conventional surfactants [23]. Dialysis post-treatment was also used for producing small and narrowly distributed nanoparticles using conventional surfactants or amphiphilic block and graft copolymers [24][25][26]. The present paper aims at reporting on the exclusive use of amphiphilic, biodegradable poly(ε-caprolactone)-grafted dextran (Dex-g-PCL) enriched in hydrophobic poly(ε-caprolactone) (PCL) for preparing surfactant-free nanoparticles through the nanoprecipitation technique.…”