2017
DOI: 10.18632/aging.101353
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Abstract: Accumulated evidence indicates that circadian genes regulate cell damage and senescence in most mammals. Endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) regulate longevity in many organisms. However, the specific mechanisms of the relationship between the circadian clock and the two stress processes in organisms are poorly understood. Here, we show that Clock-mediated Pdia3 expression is required to sustain reactive oxidative reagents and ER stress. First, ER stress and ROS are strongly act… Show more

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Cited by 62 publications
(52 citation statements)
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References 35 publications
(39 reference statements)
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“…4m, n ). Thus, we conclude that the Yap1/NF-κB axis represses the PERK and ATF6 arms of the UPR, which are associated with clock activity and survival during differentiation 29 , 54 – 56 .
Fig.
…”
Section: Resultsmentioning
confidence: 73%
See 1 more Smart Citation
“…4m, n ). Thus, we conclude that the Yap1/NF-κB axis represses the PERK and ATF6 arms of the UPR, which are associated with clock activity and survival during differentiation 29 , 54 – 56 .
Fig.
…”
Section: Resultsmentioning
confidence: 73%
“…Recent studies have established a link between the UPR and the circadian clock 29 , 54 . SAHA/JQ1 treatment upregulates multiple UPR target genes based on microarray analyses of KP cells (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Also, clock-responsive elements (E-box or E-box-like) are found in the promoter regions of antioxidative genes. Furthermore, animals deficient in clock proteins show increased reactive oxygen species generation and decreased antioxidative enzyme activity [ 9 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…Cytoplasmic dynein 1 (DYNLL1), acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules, is also reported to enhance the intracellular transport of porcine circovirus type 2 (PCV2) 31 . Circadian clocks control the processes of diseases such as inflammation, aging, virus replication and the severity of infections [32][33][34] . FBXL3 is reported to bind to a core circadian protein cryptochrome 2 (Cry2) to promote its degradation.…”
Section: Discussionmentioning
confidence: 99%