Cloacal Inoculation with the Connecticut Strain of Avian Infectious Bronchitis Virus: An Attempt to Produce Nephropathogenic Virus by in vivo Passage Using Cloacal Inoculation.

Uenaka, T.; Kishimoto, Itsuko; Uemura, Takashi; Ito, Toshihiro; Umemura, Takashi; Otsuki, Koichi

doi:10.1292/jvms.60.495

Cited by 12 publications

(2 citation statements)

References 15 publications

(21 reference statements)

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“…The ability of IBV to infect different organ systems depends on the strain of the virus. For example, infection with the Connecticut (Conn) A5968 strain of IBV is limited to replication in the respiratory tract of chickens (Cavanagh, 2005;Uenaka et al, 1998) and the virus is transmitted between individuals through the shedding of viral particles in the nasal and ocular discharge of infected birds (Cook et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens

et al. 2014

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Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of chicken, however the mechanism of generation of innate immune response against IBV infection in these tissues has not been fully characterized. Our objective was to study innate responses induced early following IBV infection in chickens. Initiation of the transcription of selected innate immune genes such as TLR3, TLR7, MyD88, IL-1β and IFN-β, as well as recruitment of macrophages, were evident following an initial down regulation of some of the observed genes (TLR3, IL-1β, and IFN-γ) in trachea and lung. This initial down-regulation followed by the induction of innate immune response to IBV infection appears to be inadequate for the control of IBV genome accumulation and consequent histopathological changes in these tissues. Potential induction of innate immunity before infection occurs may be necessary to reduce the consequences since vaccine induced immunity is slow to develop.

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Section: Introductionmentioning

confidence: 99%

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens

et al. 2014

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“…That reflex subsequently leads to absorption of the fluids on the cloacal lips into the bursa of Fabricius (Sorvari et al, 1977;van der Sluis et al, 2009). Several studies were performed to assess the bursa antigenic absorption through cloacal drinking and its ability to induce an immune response (Sorvari et al, 1977;Schlink and Olson, 1987;de Azevedo and Betti, 1993;Uenaka et al, 1998). Abaza, et al, (2020) had been conduct a study to overcome the problem of vaccine neutralization by maternally derived antibodies through direct deliver the vaccinal strains to the bursa of Fabricius via the bursal duct with no effects on maternally-derived antibodies in the blood.…”

Section: Introductionmentioning

confidence: 99%

Comparative Immunopathological Study of Various Intra-Cloacal Infectious Bursal Disease Vaccine Doses.

Abaza

ElBorai

Eissa

et al. 2020

Benha Veterinary Medical Journal

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Infectious bursal disease (IBD) is a contagious immunosuppressive viral infection of young chickens. Intra-cloacal approach is effective for vaccinating chicks with high maternally derived IBD antibodies; however, the vaccinal traditional dose may be unsuitable for this route. A total of 60 one-day-old specific-pathogen-free (SPF) chicks were randomly distributed into four groups. Group-1: was control and chicks in group-2: were vaccinated with 10 3.5 TCID50 of D78 strain/ bird via intra-cloacal route, chicks in group-3: were vaccinated with a ten-fold higher dose (10 4.5 TCID50/bird) and chicks in group-4: were vaccinated with a dose of 10 2.5 TCID50 of D78 strain/bird using same approach. IBD antibody titers were measured at the 14 th and 21 st days of age. The immunosuppressive effects of different doses were determined through humoral immune response to avian influenza and Newcastle disease vaccines, the relative weight of primary lymphoid organs, and histopathologically evaluated bursal lesions. The results indicated that a dose even ten-fold higher than the usual dose to SPF chicks via intra-cloacal route caused neither morbidity nor mortality. All vaccine doses induced potent immune responses against IBD, but the highest IBD antibodies titers were observed in group-4 while IBD antibodies titers were decreased with increasing vaccine doses in other experimental groups. Even the vaccinated birds showed moderate histopathological lesions and the diminutive relative weight of bursae; there was no immunosuppressive effect in the immune response to other vaccines in group-4 and transient immunosuppressive effect in groups-2 and-3. All that proves the safety and effectiveness of various intra-cloacal vaccination approach doses.

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Comparative Biology of Animal Coronaviruses: Lessons for SARS

Saif¹

2005

Severe Acute Respiratory Syndrome

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Cloacal Inoculation with the Connecticut Strain of Avian Infectious Bronchitis Virus: An Attempt to Produce Nephropathogenic Virus by in vivo Passage Using Cloacal Inoculation.

Cited by 12 publications

References 15 publications

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens

Comparative Immunopathological Study of Various Intra-Cloacal Infectious Bursal Disease Vaccine Doses.

Comparative Biology of Animal Coronaviruses: Lessons for SARS

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