Clioquinol Increases the Expression of VGF, a Neuropeptide Precursor, Through Induction of c-Fos Expression

Katsuyama, Masato; Ibi, Masakazu; Matsumoto, Misaki; Iwata, Kazuo; Ohshima, Yoichi; Yabe‐Nishimura, Chihiro

doi:10.1254/jphs.13271fp

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…VGF is essential for Nkx6.1‐enhanced GSIS. Given the reports linking c‐Fos with VGF , we measured VGF expression in islets overexpressing c‐Fos. AdCMV‐c‐Fos‐transduced rat islets had a 12‐fold induction of VGF at 96 h after transduction (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Nkx6.1‐mediated insulin secretion and β‐cell proliferation is dependent on upregulation of c‐Fos

et al. 2016

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Edited by L aszl o NagyUnderstanding the molecular pathways that enhance b-cell proliferation, survival, and insulin secretion may be useful to improve treatments for diabetes. Nkx6.1 induces proliferation through the Nr4a nuclear receptors, and improves insulin secretion and survival through the peptide hormone VGF. Here we demonstrate that Nkx6.1-mediated upregulation of Nr4a1, Nr4a3, and VGF is dependent on c-Fos expression. c-Fos overexpression results in activation of Nkx6.1 responsive genes and increases b-cell proliferation, insulin secretion, and cellular survival. c-Fos knockdown impedes Nkx6.1-mediated b-cell proliferation and insulin secretion. These data demonstrate that c-Fos is critical for Nkx6.1-mediated expansion of functional b-cell mass.

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Section: Resultsmentioning

confidence: 99%

“…Published reports have linked c‐Fos with Nr4a1, Nr4a3, and VGF. c‐Fos binds the VGF promoter at an AP‐1 binding site . c‐Fos activity has been associated with VGF expression in the brain .…”

Section: Discussionmentioning

confidence: 99%