Clinicopathological features of idiopathic granulomatous mastitis: A retrospective study &amp; educational lessons from Syria

Soltany, Amjad; Hraib, Munawar; Alkhayer, Mawya; Ibraheem, Batoul; Alshehabi, Zuheir

doi:10.1016/j.amsu.2022.103587

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…However, they do not infiltrate or pull the surrounding tissues, 30 hence they do not display the retraction phenomenon on ABVS images. Moreover, the infiltration of inflammatory cells, or the presence of an abscess, 31 results in lower SWE measurements than malignant lesions. The highest AUC was achieved by combining the morphological features obtained from ABVS, the lesion hardness obtained from SWE, and lesion characteristics obtained from the standard BI‐RADS system.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Significance of the BI‐RADS Classification Combined With Automated Breast Volume Scanner and Shear Wave Elastography for Breast Lesions

Ren

et al. 2022

J of Ultrasound Medicine

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Objective We herein compared the diagnostic accuracy of the BI‐RADS, ABVS, SWE, and combined techniques for the classification of breast lesions. Methods Breast lesions were appraised using the BI‐RADS classification system as well as the combinations of BI‐RADS plus ABVS (BI‐RADS + ABVS) and BI‐RADS plus SWE (BI‐RADS + SWE), and both methods (BI‐RADS + ABVS + SWE) by two specialties Medical Ultrasound physician. The Fisher's exact and χ2 tests were performed to compare the degree of malignancy for the various methods with a pathology ground truth. Receiver operating characteristic curves (ROC) were generated and the corresponding area under the curve (AUC) values were determined to test the diagnostic efficacy of the various methods and identify the optimal SWE cut‐off indicative of malignancy. Results The incidence of the retraction phenomenon on ABVS images of the malignant group was significantly higher (P < .001) than that of the benign group. The specificity, sensitivity, and positive and negative predictive values of the BI‐RADS classification were 88.72, 79.38, 83.70, and 85.50%, respectively. BI‐RADS plus SWE‐Max exhibited enhanced specificity, sensitivity, and positive and negative predictive values of 88.72, 92.78, 85.70, and 94.40%, respectively. Similarly, when BI‐RADS + ABVS was utilized, the sensitivity and negative predictive value increased to 95.88 and 96.40%, respectively. BI‐RADS + ABVS + SWE possessed the highest overall sensitivity (96.91%), specificity (94.74%), and positive (93.10%) and negative (97.70%) predictive values from all four indices. Conclusion ABVS and SWE can reduce the subjectivity of BI‐RADS. As a result, BI‐RADS + ABVS + SWE resulted in the best diagnostic accuracy.

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Section: Discussionmentioning

confidence: 99%

The Diagnostic Significance of the BI‐RADS Classification Combined With Automated Breast Volume Scanner and Shear Wave Elastography for Breast Lesions

Ren

et al. 2022

J of Ultrasound Medicine

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“…The lesions seen in general are mostly ill-defined, tough or hard, a few are soft and hard, a few are brittle, irregularly solid or cystic in section, grayish white or grayish red or grayish yellow, with dark red or yellow corn-like nodules, scattered with multiple pus cavities/ pitting foci of necrosis of varying sizes, and some describe the cystic area as decaying (27). The cystic areas contain grayish, grayish-yellow, or grayish-brown secretions, with sinus tract formation visible on the cut surface (25,(28)(29)(30)(31)(32). It has been described as a decaying cystic area containing gray, grayish-yellow, or gray-brown secretions, with sinus tract formation on the cut surface.…”

Section: Gross Examinationmentioning

confidence: 99%

Pathological manifestations of granulomatous lobular mastitis

Cui,

Sun,

Guo

et al. 2024

Front. Med.

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Granulomatous lobular mastitis (GLM) is a rare inflammatory breast disease with unknown etiology, characterized by non-caseous granulomatous inflammation of the lobules, which infiltrate lymphocytes, neutrophils, plasma cells, monocytes, and eosinophils may accompany. GLM is often misdiagnosed as breast cancer due to the lack of specificity in clinical and imaging examinations, and therefore histopathology is the main basis for confirming the diagnosis. This review provides an overview of the pathological features of granulomatous lobular mastitis and cystic neutrophil granulomatous mastitis (CNGM, a pathologic subtype of GLM). As well as pathologic manifestations of other breast diseases that need to be differentiated from granulomatous lobular mastitis such as breast tuberculosis, lymphocytic mastopathy/diabetic mastopathy, IgG4-related sclerosing mastitis (IgG4-RSM), nodular disease, Wegener’s granulomatosis, and plasma cell mastitis. Besides, discusses GLM and CNGM, GLM and breast cancer, emphasizing that their relationship deserves further in-depth exploration. The pathogenesis of GLM has not yet been clearly articulated and needs to be further explored, pathology enables direct observation of the microscopic manifestations of the disease and contributes to further investigation of the pathogenesis.

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Factors Affecting Recurrence of Idiopathic Granulomatous Mastitis: A Systematic Review

Fattahi,

Amini,

Sajedi

et al. 2023

The Breast Journal

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Idiopathic granulomatous mastitis is a rare and benign disease that primarily affects young women of reproductive age. Various factors have been suggested as possible causes, including pregnancy, breastfeeding, history of taking birth control pills, hyperprolactinemia, smoking, and history of trauma. Due to unknown etiology, opinions on its treatment have varied, resulting in differing recurrence rates and side effects. Therefore, conducting a comprehensive systematic review and meta-analysis can aid in understanding the causes and recurrence of the disease, thereby assisting in the selection of effective treatment and improving the quality of life. A systematic literature review was conducted using predefined search terms to identify eligible studies related to risk factors and recurrence up to June 2022 from electronic databases. Data were extracted and subjected to meta-analysis when applicable. A total of 71 studies with 4735 patients were included. The mean age of the patients was 34.98 years, and the average mass size was 4.64 cm. About 3749 of these patients (79.17%) were Caucasian. Patients who mentioned a history of pregnancy were 92.65% with 76.57%, 22.7%, and 19.7% having a history of breastfeeding, taking contraceptive pills, and high prolactin levels, respectively. Around 5.6% of patients had previous trauma. The overall recurrence rate was 17.18%, with recurrence rates for treatments as follows: surgery (22.5%), immunosuppressive treatment (14.7%), combined treatment (14.9%), antibiotic treatment (6.74%), and observation (9.4%). Only antibiotic and expectant treatments had significant differences in recurrence rates compared to other treatments ( p value = 0.023). In conclusion, factors such as Caucasian race, pregnancy and breastfeeding history, and use of contraceptive hormone are commonly associated with the disease recurrence. Treatment should be tailored based on symptom severity and patient preference, with surgery or immunosuppressive options for recurrence.

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Clinicopathological features of idiopathic granulomatous mastitis: A retrospective study & educational lessons from Syria

Cited by 3 publications

References 16 publications

The Diagnostic Significance of the BI‐RADS Classification Combined With Automated Breast Volume Scanner and Shear Wave Elastography for Breast Lesions

The Diagnostic Significance of the BI‐RADS Classification Combined With Automated Breast Volume Scanner and Shear Wave Elastography for Breast Lesions

Pathological manifestations of granulomatous lobular mastitis

Factors Affecting Recurrence of Idiopathic Granulomatous Mastitis: A Systematic Review

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