Clinicopathological features and prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgery

Lee, Seung Duk; Park, Sang-Jae; Han, Sung‐Sik; Kim, Seong Hoon; Kim, Young-Kyu; Lee, Soon-Ae; Ko, Yousang; Hong, Eun Kyung

doi:10.1016/s1499-3872(14)60275-7

Cited by 63 publications

(73 citation statements)

References 26 publications

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“…HBV infection was significantly more common among patients with CHC or HCC compared with ICC. These results were largely in accord with previous reports indicating similar tumorigenic backgrounds for CHC and HCC . The incidences of elevated AFP, PIVKAII, CEA, and CA19‐9 in patients with CHC were 64.3%, 50.0%, 25.0%, and 50.0%, respectively, which were similar to those reported in previous studies .…”

Section: Discussionsupporting

confidence: 92%

Clinical and pathological features of combined hepatocellular–cholangiocarcinoma compared with other liver cancers

Wakizaka

Yokoo

Kamiyama

et al. 2018

J of Gastro and Hepatol

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Background and Aim Combined hepatocellular–cholangiocarcinoma (CHC) is a primary liver cancer containing both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) elements. Its reported clinicopathological features and prognoses have varied because of its low prevalence. This study aimed to clarify these aspects of CHC. Methods We enrolled 28 patients with CHC, 1050 with HCC, and 100 with ICC and compared the clinicopathological characteristics and prognosis of CHC with HCC and ICC. We also analyzed prognostic factors, recurrence patterns, and management in CHC patients. Results The incidences of hepatitis B virus and high α‐fetoprotein and protein induced by vitamin K absence or antagonists‐II levels were significantly higher among CHC compared with ICC patients. Multiple tumors were more frequent in CHC compared with the other groups, while vascular invasion and lymph node metastasis were more frequent in the CHC than the HCC group. The 5‐year overall survival and disease‐free survival rates for CHC were 25.1% and 22.6%, respectively. Overall survival was significantly lower than for HCC (P < 0.001) but not ICC (P = 0.152), while disease‐free survival was significantly lower than for HCC and ICC (P = 0.008 and P = 0.005, respectively). Multivariate analysis identified carcinoembryonic antigen levels and tumor size as independent predictors in patients with CHC. Conclusions The clinical features of CHC, including sex, hepatitis B virus infection, α‐fetoprotein, and protein induced by vitamin K absence or antagonists‐II levels, were similar to HCC, while its prognosis and pathological features, including vascular invasion and lymph node metastasis, were similar to ICC. Carcinoembryonic antigen levels and tumor size were independent prognostic factors in patients with CHC.

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Section: Discussionsupporting

confidence: 92%

Clinical and pathological features of combined hepatocellular–cholangiocarcinoma compared with other liver cancers

Wakizaka

Yokoo

Kamiyama

et al. 2018

J of Gastro and Hepatol

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“…In our study, cHCC-CC was male predominant in the middle 50s with high hepatitis B viral infection rate and elevated AFP level, more like HCC, consistent with previous studies [6,9,11]. Overall, tumors in the fibrotic and cirrhotic livers were smaller than those in the normal liver, which may be corresponded to a more frequent follow-up in these patients, thus regular surveillance may be necessary.…”

Section: Discussionsupporting

confidence: 90%

MR comparative study of combined hepatocellular-cholangiocarcinoma in normal, fibrotic, and cirrhotic livers

Sheng

Xie

et al. 2016

Abdom Radiol

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“…Hepatocellular cholangiocarcinomas (HCC-CCs) are primary liver composite carcinomas with biphenotypic differentiation that stem from either common progenitor cell lineages or the dedifferentiation of mature liver cells [9]. Studies indicate that HCC-CCs have a worse prognosis than either HCC or CC alone [10][11][12][13][14][15][16]. Treatment modalities include local radiofrequency ablative therapy, chemotherapy, transarterial chemoembolization, liver transplantation, and radical resection, which is preferred over nonoperative management in terms of survival outcome (16.5 months) [13,15,17,18].…”

Section: Hepatobiliary Composite Tumorsmentioning

confidence: 99%

Collision and composite tumors; radiologic and pathologic correlation

et al. 2017

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The terms composite and collision tumors have been used interchangeably throughout radiological literature. Both composite and collision tumors involve two morphologically and immunohistochemically distinct neoplasms coexisting within a single organ. However, collision tumors lack the histological cellular intermingling seen in composite tumors. Composite tumors often arise from a common driver mutation that induces a divergent histology from a common neoplastic source while collision tumors may arise from coincidental neoplastic change. The purpose of this review is to provide an overview of abdominal composite and collision tumors by discussing hallmark radiographic and pathological presentations of rare hepatic, renal, and adrenal case studies. A better understanding of the presentation of each lesion is imperative for proper recognition, diagnosis, and management of these unique tumor presentations.

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Clinicopathological features and prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgery

Cited by 63 publications

References 26 publications

Clinical and pathological features of combined hepatocellular–cholangiocarcinoma compared with other liver cancers

Clinical and pathological features of combined hepatocellular–cholangiocarcinoma compared with other liver cancers

MR comparative study of combined hepatocellular-cholangiocarcinoma in normal, fibrotic, and cirrhotic livers

Collision and composite tumors; radiologic and pathologic correlation

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