Clinicopathological Characteristics of Colon Cancer Diagnosed at Primary Health Care Institutions

Abstract

Background/AimsThe purpose of this study was to evaluate the clinicopathologic characteristics of colon cancers detected at the SOK Sokpeynhan Internal Medical Network, a nationwide system of primary health care institutions.MethodsWe analyzed 579 colon cancer patients diagnosed using colonoscopy at the SOK network from January 2011 through December 2012. Cancers from the rectum to the splenic flexure were classified as left colon cancer. Patients over 65 were classified as senior.ResultsThe mean age (±SD) of subjects was 60.9±10.5 years and 61.1% were men. More than one quarter (28.2%) of patients were asymptomatic. The prevalence of left colon cancer was higher (77.9%) than that for right colon cancer. The most frequent macroscopic and histologic types were depressed (58.9%) and moderately differentiated adenocarcinoma (52.2%), respectively. Asymptomatic subjects displayed protruding or well differentiated adenocarcinoma, while symptomatic patients were more likely to display depressed or moderately differentiated adenocarcinoma (P<0.05). The mean age of the right colon cancer group was higher than that for the left colon cancer group (P<0.05). Among symptomatic patients, the most frequent symptoms were bloody stool for patients with left colon cancer and abdominal discomfort for patients with right colon cancer (P<0.05). The prevalence of depressed cancer was higher in older subjects as compared to younger subjects (P<0.05). The prevalence of right colon cancer tended to increase with age, although this difference did not achieve statistical significance (P>0.05).ConclusionsStudy results indicated an increase of colon cancer amongst younger demographics in recent years. The effectiveness of colonoscopy screening was also evident, as asymptomatic patients demonstrated frequent findings of well differentiated adenocarcinomas. Study results also suggested a need for closer examination of older patients, as right colon cancer tended to increase with age.

Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

“…Moreover, arsenic compounds also induce clinical remission in patients with acute promyelocytic leukaemia [24] and dermatological disease [25], and may represent a potential treatment for other cancers [26][27][28][29]. The first proof of the As/Se interaction in relation to cancer was found in mice [30] and rats [31], when As III antagonized the carcinogenic effect of Se IV .…”

Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer

“…According to the annual report of the Korea Central Cancer Registry, a total of 24,986 CRC cases detected in Korea in 2009, representing 13.0% of all incident cancer cases [3, 4]. CRC is the second and third most common cancer in Korean men and women, respectively [3, 4]. …”

Risk of developing advanced colorectal neoplasia after removing high‐risk adenoma detected at index colonoscopy in young patients: A KASID study

“…Therefore, prevention and the early detection of CRC by colonoscopy have become topics of interest . Screening is performed to identify and remove precursor adenoma and is recommended in those > 50 aged years because of the low incidence of CRC before age of 50 in the general population . However, the incidence and mortality rates of CRC in adults aged < 50 years have been increasing .…”

“…3 Screening is performed to identify and remove precursor adenoma and is recommended in those > 50 aged years because of the low incidence of CRC before age of 50 in the general population. [4][5][6][7] However, the incidence and mortality rates of CRC in adults aged < 50 years have been increasing. [8][9][10] Regarding advanced adenoma, several studies have reported the prevalence and risk factors in young adults (< 50 years), when advanced adenoma was defined as an adenoma at least 10 mm in diameter high-grade dysplasia (HGD), villous or tubulovillous histologic characteristics, or any combination thereof.…”