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Cited by 51 publications
(20 citation statements)
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“…Xenon offers many advantages over routinely used gases.7 It is non-explosive; probably does not undergo biotransformation; is non-toxic; and offers rapid induction of and recovery from anaesthesia. [8][9][10][11] In experimental studies we have measured tooth-pulp evoked potentials to evaluate pain12,13 and confirmed that the analgesic efficacy of xenon is superior to that of nitrous oxide at the same concentration (70%);14 xenon had no effect on systemic haemodynamics or local organ perfusion15 as measured by means of radionuclidelabelled microspheres. 16,17 The …”
Section: Introductionmentioning
confidence: 79%
“…Xenon offers many advantages over routinely used gases.7 It is non-explosive; probably does not undergo biotransformation; is non-toxic; and offers rapid induction of and recovery from anaesthesia. [8][9][10][11] In experimental studies we have measured tooth-pulp evoked potentials to evaluate pain12,13 and confirmed that the analgesic efficacy of xenon is superior to that of nitrous oxide at the same concentration (70%);14 xenon had no effect on systemic haemodynamics or local organ perfusion15 as measured by means of radionuclidelabelled microspheres. 16,17 The …”
Section: Introductionmentioning
confidence: 79%
“…At present,no evidence is available to relate these possibilities to either survival or the extent of lung injury. Speculatively, effects on nerve tissue [8,21,33] would have direct conse quences on ventilation through the neuromuscular apparatus [46]. Once again, the behavior of the mixtures with SF6 pose special problems in this regard ( fig.…”
Section: Systemic Influences O F Noble Gasesmentioning
confidence: 99%
“…This gas has a molecular weight of 131.3, close enough to that of sulfur hexafluo ride (146) to aid in a rough comparison made necessary by the scanty lit erature on SF6. Xenon seems to have definite effects, including anesthet ic properties at less than 1 atmosphere absolute [7,8,15,24,33,34]. If SF6…”
Section: Systemic Influences O F Noble Gasesmentioning
confidence: 99%
“…The noble gas xenon has been used as a general anesthetic since the 1950s [18,19] but its molecular targets were unknown [20]. Following the discovery that xenon is an NMDA receptor antagonist [21][22][23][24], xenon was shown to be neuroprotective in a number of in vitro and in vivo models of ischemic injury [25][26][27][28][29][30][31][32][33][34] and xenon is currently undergoing clinical trials as a treatment for ischemic brain injury [35,36] and post-operative delirum [37].…”
Section: Introductionmentioning
confidence: 99%