Clinicopathologic features of encapsulated hepatocellular carcinoma.A study of 26 cases

Okuda, Kunio; Musha, Hirotaka; Nakajima, Yutsuki; Kubo, Yasuhiko; Shimokawa, Yutaka; Nagasaki, Yoshikazu; Sawa, Yasuhiko; Jinnouchi, Shigenobu; Kaneko, Toshioki; Obata, Hiroshi; Hisamitsu, T; Motoike, Yoji; Okazaki, Nobuo; Kojiro, Masamichi; Sakamoto, Kazuyoshi; Nakashima, Toshiro

doi:10.1002/1097-0142(197709)40:3<1240::aid-cncr2820400339>3.0.co;2-y

Cited by 155 publications

(63 citation statements)

References 5 publications

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“…If alcohol can induce HCC more directly or if tumour development always requires existent cirrhosis is not known. HCC, however, has also been reported in alcoholics without cirrhosis (Anthony, 1976 (Okuda, 1977). Of the 15 cases with CC, 6 were alcoholics with a crude ratio of 3.3, which was not significant, (X2 = 2.…”

Section: Discussionmentioning

confidence: 91%

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Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria - an epidemiological investigation

Hardell¹,

Bengtsson²,

Jonsson³

et al. 1984

Br J Cancer

178

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Some environmental factors of possible aetiological importance for primary liver carcinoma (PLC) in males were analysed in a case-control study including 83 cases of hepatocellular carcinoma (HCC), 15 cases of intrahepatic cholangiocellular carcinoma (CC), 3 cases of haemangiosarcoma and 1 case of unspecified sarcoma in the liver--102 cases in total. Two matched controls were used in each case. One case with haemangiosarcoma was exposed to polyvinyl chloride. The case with unspecified soft-tissue sarcoma was exposed to phenoxy acids. A 4-fold increase in the risk of HCC was seen in alcoholics, and regular drinking gave a 3-fold increase in the risk. Exposure to organic solvents gave a 2-fold increase in the risk of HCC. No increased risk was observed for cases exposed to various other chemicals. Three cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases of HCC had a previous diagnosis of porphyria acuta intermittens (PAI), versus no control. Six cases with PLC had polyphyria cutanea tarda (PCT) which in 4 cases was related to alcoholism and in one case to haemochromatosis.

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Section: Discussionmentioning

confidence: 91%

“…The most predominant histological type of PLC is hepatocellular carcinoma (HCC). Intrahepatic cholangiocellular carcinoma (CC) is less common than HCC and is thought to have a different aetiology (Okuda et al, 1977). HCC has been associated with hepatitis B virus, aflatoxins and alcohol with -75% of cases occurring in patients with cirrhosis (Popper, 1979).…”

mentioning

confidence: 99%

Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria - an epidemiological investigation

Hardell¹,

Bengtsson²,

Jonsson³

et al. 1984

Br J Cancer

178

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“…Neither PAI nor PEI group patients showed a significant change at the time of discharge from the pretreatment value in the serum levels of GOT (IU/dL: 88 Ϯ 41 vs. compared with ethanol. 25,26 The presence of a fibrous capsule and fibrous septa within the mass is one of the gross characteristics of HCC in the Far East, 36 and a most helpful diagnostic clue in imaging. 37,38 Encapsulated HCC also occurs among non-Asian patients.…”

Section: Resultsmentioning

confidence: 99%

Prospective randomized controlled trial comparing percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma

et al. 1998

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To assess whether ultrasound-guided percutaneous acetic acid injection is superior to percutaneous ethanol injection in the treatment of small hepatocellular carcinoma (HCC), 60 patients with one to four HCCs smaller than 3 cm were entered onto a randomized controlled trial. Thirty-one and 29 patients, respectively, were treated by percutaneous acetic acid injection using 50% acetic acid or by percutaneous ethanol injection using absolute ethanol. There were no significant differences in age, sex ratio, Child-Pugh class, size of tumors, or number of tumors between the two groups. When there was no evidence of viable HCC from biopsy, plain and helical dynamic computed tomography, or angiography, the treatment was considered successful and was discontinued. All original tumors were treated successfully by either therapy. However, 8% of 38 tumors treated with percutaneous acetic acid injection and 37% of 35 tumors treated with percutaneous ethanol injection developed a local recurrence (P F .001) during the follow-up periods of 29 ؎ 8 months and 23 ؎ 10 months, respectively. The 1-and 2-year survival rates were 100% and 92% in percutaneous acetic acid injection and 83% and 63% in percutaneous ethanol injection (P ‫؍‬ .0017). A multivariate analysis of prognostic factors revealed that treatment was an independent predictor of survival. The risk ratio of percutaneous acetic acid injection versus percutaneous ethanol injection was 0.120 (range, 0.027-0.528; P ‫؍‬ .0050). In conclusion, percutaneous acetic acid injection is superior to percutaneous ethanol injection in the treatment of small HCC. (HEPATOLOGY 1998;27:67-72.)Hepatocelluar carcinoma (HCC) is one of the major malignancies with poor prognosis in eastern Asia, especially China, Japan, Taiwan, Singapore, and Korea, as well as Sub-Saharan Africa 1 ; the estimated incidence is approximately 1,250,000 deaths per year worldwide. 2 The early detection strategies for HCC have increased the number of small resectable HCCs in regions where they are endemic. [3][4][5] The survival rates reported after resection have improved in the last decade, mainly because of the increasingly smaller sizes of resected tumors. 4-9 Some surgical teams have thus achieved a 50% 5-year rate of survival in patients with small, asymptomatic HCCs. 5,6 However, resection is possible in a small proportion of patients because of the underlying advanced cirrhosis. Orthotopic liver transplantation is also an effective treatment for small, unresectable HCCs, but potential recipients far outnumber donors.Such difficulty in the management of HCC prompted the development of other potentially curative therapeutic modalities such as transcatheter hepatic arterial embolization (TAE) 13,14 and ultrasound (US)-guided percutaneous injection of materials that will kill cancer cells. [15][16][17][18][19][20][21][22] The latter is indicated for both hypervascular and hypovascular HCCs, whereas TAE is only for hypervascular HCCs; small HCCs are frequently hypovascular. Percutaneous ethanol injection (PEI) is...

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“…The prognosis of HCC is still very poor, because it develops multicentrically and is associated in most cases with chronic liver diseases. [1][2][3] Furthermore, invasion of HCC to the peritoneum causes malignant ascites, which is experienced frequently in patients with advanced HCC. The patient's quality of life with this condition is seriously decreased as a result of the abdominal distension and pressure on the chest cavity.…”

mentioning

confidence: 99%

The vascular endothelial growth factor receptor KDR/Flk-1 is a major regulator of malignant ascites formation in the mouse hepatocellular carcinoma model

Yoshiji

Kuriyama

Hicklin³

et al. 2001

Hepatology

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Clinicopathologic features of encapsulated hepatocellular carcinoma.A study of 26 cases

Cited by 155 publications

References 5 publications

Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria - an epidemiological investigation

Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria - an epidemiological investigation

Prospective randomized controlled trial comparing percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma

The vascular endothelial growth factor receptor KDR/Flk-1 is a major regulator of malignant ascites formation in the mouse hepatocellular carcinoma model

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