Clinicopathologic Correlations in Diabetic Retinopathy

<p>Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion</p>

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<p>Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion</p>

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Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects

“…It is encouraging that these results also are in agreement with histological studies of microaneurysm appearance. 10,11,13 We consistently observed that areas of impaired capillary perfusion are more distinct on OCTA than corresponding fluorescein angiograms of "capillary non-perfusion." The higher resolution of small vessels on OCTA also allowed observation of capillary loops on OCTA that were not visible clinically or on fluorescein angiography.…”

“…[10][11][12] One histological study of a cadaver eye with fluorescein angiography performed prior to enucleation noted that several microaneurysms' appearance on fluorescein angiography were so out of proportion to their appearance on histology that they would not have been recognized histologically if not for the fluorescein angiogram. 13 The difference could only be ascribed to fluorescein leakage and staining of the microaneurysm wall. Since OCTA does not detect leakage and staining, microaneurysms may appear both smaller and more irregular in shape on OCTA making them more difficult to readily detect.…”

Relationship between Functional and Structural Changes in Diabetic Vessels in Optical Coherence Tomography Angiography

“…Some microaneurysms may have no erythrocytes or blood cells with less motility, which could not be visualized in the OCTA images, although the movement of erythrocytes is not constant in the microaneurysms 37 . Histologic studies have reported saccular or fusiform microaneurysms, and OCTA showed similar morphologies in some microaneurysms 30 34 38 39 . We also sometimes observed curved or coiled capillaries corresponding to hyperfluorescent dots in the FA images.…”

<p>Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion</p>

“……”

Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects

“…It is encouraging that these results also are in agreement with histological studies of microaneurysm appearance. 10,11,13 We consistently observed that areas of impaired capillary perfusion are more distinct on OCTA than corresponding fluorescein angiograms of "capillary non-perfusion." The higher resolution of small vessels on OCTA also allowed observation of capillary loops on OCTA that were not visible clinically or on fluorescein angiography.…”

“…[10][11][12] One histological study of a cadaver eye with fluorescein angiography performed prior to enucleation noted that several microaneurysms' appearance on fluorescein angiography were so out of proportion to their appearance on histology that they would not have been recognized histologically if not for the fluorescein angiogram. 13 The difference could only be ascribed to fluorescein leakage and staining of the microaneurysm wall. Since OCTA does not detect leakage and staining, microaneurysms may appear both smaller and more irregular in shape on OCTA making them more difficult to readily detect.…”

Relationship between Functional and Structural Changes in Diabetic Vessels in Optical Coherence Tomography Angiography

“…Some microaneurysms may have no erythrocytes or blood cells with less motility, which could not be visualized in the OCTA images, although the movement of erythrocytes is not constant in the microaneurysms 37 . Histologic studies have reported saccular or fusiform microaneurysms, and OCTA showed similar morphologies in some microaneurysms 30 34 38 39 . We also sometimes observed curved or coiled capillaries corresponding to hyperfluorescent dots in the FA images.…”

<p>Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion</p>

“……”

Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects

“…It is encouraging that these results also are in agreement with histological studies of microaneurysm appearance. 10,11,13 We consistently observed that areas of impaired capillary perfusion are more distinct on OCTA than corresponding fluorescein angiograms of "capillary non-perfusion." The higher resolution of small vessels on OCTA also allowed observation of capillary loops on OCTA that were not visible clinically or on fluorescein angiography.…”

“…[10][11][12] One histological study of a cadaver eye with fluorescein angiography performed prior to enucleation noted that several microaneurysms' appearance on fluorescein angiography were so out of proportion to their appearance on histology that they would not have been recognized histologically if not for the fluorescein angiogram. 13 The difference could only be ascribed to fluorescein leakage and staining of the microaneurysm wall. Since OCTA does not detect leakage and staining, microaneurysms may appear both smaller and more irregular in shape on OCTA making them more difficult to readily detect.…”

Relationship between Functional and Structural Changes in Diabetic Vessels in Optical Coherence Tomography Angiography

“…Some microaneurysms may have no erythrocytes or blood cells with less motility, which could not be visualized in the OCTA images, although the movement of erythrocytes is not constant in the microaneurysms 37 . Histologic studies have reported saccular or fusiform microaneurysms, and OCTA showed similar morphologies in some microaneurysms 30 34 38 39 . We also sometimes observed curved or coiled capillaries corresponding to hyperfluorescent dots in the FA images.…”