Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014

Ma, I-Hsin; Hu, Fung‐Rong; Wang, I‐Jong; Chen, Wei-Li; Hsu, Ya-Jui; Chu, Hsiao-Sang; Yuan, Chang‐Tsu; Hou, Yu-Chih

doi:10.1016/j.jfma.2018.09.001

Cited by 13 publications

(22 citation statements)

References 24 publications

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“…According to the previous studies OSSN is commonly seen in elderly and in males in Asia, Europe, Australia and North America, but not in Africa [2,5,8,11,24,25]. In Africa prevalence is more in young and females [5,8,11,24], this may be due to increased prevalence of HIV infection in Africa. Generally male preponderance is seen as men are exposed to more UV light due to more outdoor activities.…”

Section: Discussionmentioning

confidence: 89%

“…Demographic profile of patients with OSSN differ in different parts of the world [5]. The average age of presentation is usually the sixth and seventh decades of life.…”

Section: Discussionmentioning

confidence: 99%

“…However in patients with systemic predisposing conditions HIV infection, xerodermapigmentosa, OSSN may occur at a younger age [1,8,17,19]. According to the previous studies OSSN is commonly seen in elderly and in males in Asia, Europe, Australia and North America, but not in Africa [2,5,8,11,24,25]. In Africa prevalence is more in young and females [5,8,11,24], this may be due to increased prevalence of HIV infection in Africa.…”

Section: Discussionmentioning

confidence: 99%

“…Ocular Surface Squamous Neoplasia (OSSN) is the most common malignancy of the ocular surface. It encompasses wide spectrum of histological diagnoses ranging from mild intraepithelial dysplasia to invasive squamous cell carcinoma (SCC) of the conjunctiva and cornea [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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A report on the outcome of topical mitomycin C as the primary treatment for ocular surface squamous neoplasia

SS¹,

GS²,

DN³

et al. 2022

J Med Sci Res.

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Background: Although surgical excision is still the gold standard treatment for ocular surface squamous neoplasia (OSSN), interest in conservative medical approaches is steadily growing due to its advantages. The clinical outcome of topical mitomycin C (MMC) as the primary treatment for OSSN was reported. The primary outcome measure was clinical regression of the tumour. The secondary Outcome measures were duration of treatment, possible side effects and recurrences. Materials and methods: In this prospective study 11 patients with the diagnosis of OSSN were included. All were treated with mitomycin C eye drops 0.02% 4 times daily for 4 days a week. Results: Out of the 11 patients, complete tumour regression was achieved in 6 (54.5%) patients. The remaining 5 patients reported partial tumour regression. Mean duration of treatment was 6 weeks. The most common side effect noted was eye irritation. The side effect was transient and resolved with the cessation of treatment. No recurrence was observed during the follow up. Conclusion: Topical chemotherapy can be tried as primary treatment in all patients with OSSN as it can cause complete or partial tumour regression with negligible side effects. Keywords: ocular surface squamous neoplasia; mytomycin C; tumour regression

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Section: Discussionmentioning

confidence: 89%

“…Demographic profile of patients with OSSN differ in different parts of the world [5]. The average age of presentation is usually the sixth and seventh decades of life.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A report on the outcome of topical mitomycin C as the primary treatment for ocular surface squamous neoplasia

SS¹,

GS²,

DN³

et al. 2022

J Med Sci Res.

View full text Add to dashboard Cite

show abstract

“…Grading of dysplasia was made based on cellular atypia and the amount of thickness involvement. Conjunctival intra epithelial neoplasia (CIN) was graded as mild, moderate, or severe according to the thickness and degree of cellular atypia; according to the standard protocol 12. In all three grades, cells with atypia are restricted by the basement membrane.…”

Section: Methodsmentioning

confidence: 99%

<p>Expression of interleukin-6 in ocular surface squamous neoplasia</p>

Eghtedari

Beigi

Maalhagh

et al. 2019

OPTH

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Purpose Interleukin-6 (IL-6) is an important cytokine in the cascade of inflammation and cancer progression. The aim of this study was to identify IL-6 expression in ocular surface squamous neoplasia (OSSN) in comparison with non-neoplastic conjunctival tissue. Methods Twenty paraffin-embedded tissue sections of conjunctiva from patients with OSSN including conjunctival intraepithelial neoplasia (CIN) in all grades of severity and squamous cell carcinoma (SCC) were assessed by immunohistochemistry staining for IL-6. Twenty non-neoplastic conjunctival sections from age matched patients were selected as the control group. Tissues with more than one focus of inflammatory cell infiltration were excluded from the study. The mean area of positive staining was recorded and the intensity of staining was scored in both groups and compared by statistical methods. Results The mean staining area in the dysplasia group was significantly more than non-neoplastic conjunctival tissue (63.5±25.96 and 30±15.98 percent respectively; P -value of <0.0001). Nuclear staining was observed in both groups and the difference was not statistically significant. Conclusion IL-6 expressed more in the dysplastic group in compare to non-neoplastic conjunctiva and can therefore be used to diagnose dysplastic state of the conjunctiva; however, in our study, intensity of staining does not correlate with the severity of dysplasia statistically; most probably because of a low sample size in each category. The role of nuclear staining is not clear. Our findings can be an introduction toward targeted treatment of ocular surface neoplasia by the aim of newer anti-IL agents. Further investigation is needed.

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Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review

et al. 2020

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Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014

Cited by 13 publications

References 24 publications

A report on the outcome of topical mitomycin C as the primary treatment for ocular surface squamous neoplasia

A report on the outcome of topical mitomycin C as the primary treatment for ocular surface squamous neoplasia

<p>Expression of interleukin-6 in ocular surface squamous neoplasia</p>

Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review

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