Clinicopathologic Correlation of Cutaneous Metastases

Abstract

Setting: Comprehensive cancer center.Patients: Fifty-one patients (21 men and 30 women) with biopsy-proven skin metastases and correlative clinical data.Interventions: Four dermatopathologists reviewed a random mixture of metastases and primary skin tumors. Immunohistochemical studies for 12 markers were performed on the metastases, with skin adnexal tumors as controls.Main Outcome Measures: Clinical characteristics of cutaneous lesions, clinical outcomes, histologic features, and immunohistochemical markers.Results: Eighty-six percent (43 of 50) of the patients had known stage IV cancer, and skin metastasis was the pre-

A Rare Case of Zosteriform Cutaneous Metastases from Squamous Cell Carcinoma of Hard Palate

“…Generally, the histological features of the metastases are similar to those of the primary tumor, although metastases may be more anaplastic and exhibit less differentiation. [10] Contrary to the published literature, in our case, the histology of the primary carcinoma of hard palate showed infiltrative squamous cell carcinoma and the zosteriform cutaneous metastases revealed squamous cell carcinoma secondaries. Rao, et al .…”

A retrospective review of cutaneous metastases at the National Skin Centre Singapore

“…For example, some studies included skin involvement from the direct infiltration of breast cancer and metastases from primary skin and/or haematological malignancies . Table compares data from four studies in different countries that employed largely similar inclusion criteria to ours. In summary, similar findings include the fact that the majority of the patients are women, the mean age at diagnosis was in the patients' sixties, the commonest primary in women was the breast, the most frequent site of metastases was the chest and the commonest morphology was a nodule.…”

“…The high frequency of breast cancer in our study is consistent with previous studies and can be attributed to the high incidence of breast cancer in Singapore and throughout the world . The mammary gland is a specialised epidermal appendage and the signalling pathways necessary in mammary gland embryogenesis, such as those involving Wnt, hedgehog, fibroblast growth factor, epidermal growth factor and insulin‐like growth factor 1 are known to be recapitulated in breast cancer and metastases .…”

Cutaneous metastases from different internal malignancies: a clinical and prognostic appraisal

“…Other common sources of cutaneous metastases included the colon and rectum, oral mucosa and stomach. This is consistent with studies involving Caucasian populations 7,11,12,14,17–19 . Therefore, although the most frequent primary tumours encountered are different, the origins of skin metastases seemed similar among these two ethnic populations.…”