Clinico-pathological study of colonoscopic biopsies in patients with chronic diarrhea

Atla, Bhagyalakshmi; Venkatalakshmi, A.; Praveen, L S; Sunilkumar, K

doi:10.18203/2320-6012.ijrms20161942

Cited by 3 publications

(8 citation statements)

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“…The most common pathological diagnosis was NSCC, followed by malignancy, then IBD. Bhagyalakshmi et al agreed with our findings as they found that non-specific inflammation was the most common diagnosis, affecting 60% of patients who presented with chronic diarrhea, followed by malignancy and UC (12.5%) (4) . (13) Pati et al found different results where the most common colonoscopic finding was hemorrhoids, followed by colorectal growths, then UC (14) .…”

Section: Discussionsupporting

confidence: 91%

“…To achieve this result, it is paramount to early identify the clinical symptoms that correlate to those findings. For example, diarrhea is correlated with colitis; bleeding per rectum and abdominal pain are linked to colon cancer and colorectal polyps; and bloody diarrhea is related to IBD (2,4) . Apart from the clinical picture, the patient's characteristics assist in prediction of specific diagnoses.…”

Section: Introductionmentioning

confidence: 99%

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Colonoscopic and Histopathological Findings in Patients with Various Lower Gastrointestinal Symptoms: A Single-Center Experience

Moussa

Gawad

Nosseir

et al. 2020

Suez Canal University Medical Journal

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Background: Early diagnosis of lower gastrointestinal (GI) diseases constitutes a challenge. While colonoscopy helps in the detection of these diseases; histopathological analysis of obtained biopsies is of greater importance. Aim: This study aimed at the identification of colonic lesions associated with common lower GI manifestations based on colonoscopy and histopathological examination of biopsies. Materials and Methods: In a retrospective cross-sectional study, we included medical records of 710 patients involving their personal, clinical, endoscopic, and pathological data. Included data were of patients who presented with lower GI manifestations, and underwent colonoscopy and biopsy taking in the period from January 2016 to June 2020. Results: The most found pathology was non-specific chronic colitis (NSCC) (59.7%), followed by malignancy 19.3%) then inflammatory bowel disease (IBD) (15.6%), hyperplastic inflammatory polyp in 3.7%. Meanwhile, bilharzial colitis was diagnosed in 1.3% of patients. Significant predictors of both NSCC and malignancy were advanced age (<0.001), diabetes, hypertension, abdominal pain, diarrhea, and bloody diarrhea. In addition, bleeding per rectum and weight loss were also found to be specific predictors in malignancy. The only predictors of IBD were abdominal pain and bloody diarrhea and weight loss. Conclusions: NSCC, malignancy, and IBD are the most common causes of lower GI manifestations. Moreover, clinical predictors of these diseases are useful in the early diagnosis and management of colonic lesions.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Colonoscopic and Histopathological Findings in Patients with Various Lower Gastrointestinal Symptoms: A Single-Center Experience

Moussa

Gawad

Nosseir

et al. 2020

Suez Canal University Medical Journal

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“…Comparing the present study with other studies, male preponderance was also found in study done by Bhagyalaxmi et al 8 Degaonkar et al 9 study showed maximum no of patients presented with pain in abdomen while in present study most common complaint was loose stool but vomiting was the least common symptom in both the studies. The most common endoscopic finding in this study was erosion while in Degaonkar et al 9 study it was ulcerative growth, it may differ because of subjective judgment of gastroenterologist.…”

Section: Discussionsupporting

confidence: 87%

“…Also, a wide range of HPE diagnosis were observed in non-neoplastic cases, as there is very broad spectrum of cases and no standard protocol is available to report. The most common non-neoplastic diagnosis was chronic nonspecific colitis which was similar finding when compared with the study of Bhagyalaxmi et al 8 and Rangaswamy et al 10 Qayyum et al study 11 showed difference in reporting of non-neoplastic lesions because of lack of standard criteria to diagnose. Strong concordance is observed when benign neoplastic lesions were compared with study done by Randale A et al 12 While comparing malignant neoplastic lesions with other studies, Umano et al 13 study showed maximum no of well differentiated adenocarcinoma cases while in this study it was moderately differentiated adenocarcinoma, which was similar finding when compared with Karve SH et al 14 and Rangaswamy et al 10 studies.…”

Section: Discussionsupporting

confidence: 77%

Histopathological study of endoscopic biopsies of large intestine

Kulkarni

Karandikar²,

Mulay³

et al. 2021

IJPO

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The large intestine is a site of a variety of diseases. The lesions tend to occur affecting different age groups ranging from early childhood to late adulthood. Patients may present with very vague clinical symptoms ranging from abdominal pain, loose stools, vomiting, diarrhoea, bleeding per rectum, and change in bowel habit. Patients presenting with repeated symptoms related to lower intestinal pathology are advised to undergo colonoscopic examination.To study clinico-pathological correlation of endoscopic biopsies of large intestine and to study spectrum of large intestinal lesions.The study was conducted at a tertiary care hospital from August 2018 to July 2020. All endoscopic biopsy samples were included in this study. All endoscopic biopsies were performed by high definition colonoscope. Clinical and endoscopic correlation with histopathological diagnosis was performed and results were generated.Total 133 cases were included in this study, out of 133 patients 86 were males and 47 were females. Patients showed wide age range from 11 years to 80 years. There were 25 patients each in age group of 31-40 years and 61-70 years. The most common presenting complaint was loose stools in 66 cases. The most common endoscopic finding was erythema in 82 cases. Out of 133 cases, 105 cases were non neoplastic, 08 cases were benign neoplastic and 20 cases were malignant neoplastic on histopathology.Colonoscopy is very high yielding and safe procedure to perform.Colonoscopic biopsies are proven to be of great importance. Clinical, endoscopic and histopathological correlation is always advisable in large intestinal pathology for early diagnosis and treatment.

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“…Different results were reported by Bhagyalakshmi et al and Javier et al, the majority of colonoscopy findings were ulcerations. 10,13 Moussa et al stated that the difference might manifest in different patient characteristics and clinical manifestations, which affected colonoscopy findings. 14 This study discovered that colonoscopy features mostly found hyperemic edema, followed by ulceration.…”

Section: Discussionmentioning

confidence: 99%

Colonoscopy and Histopathologic Features in Chronic Diarrhea Patients at Dr. Hasan Sadikin General Hospital Bandung

Rasdianto

Nugraha

Usman

et al. 2022

InaJGHE

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Background: Diagnosis and treating patients with chronic diarrhea are challenging due to broad differential diagnoses. An adequate examination leads to a specific diagnosis and appropriate management. Colonoscopy with biopsy is indicated to establish chronic diarrhea etiologies. No previous data demonstrated the colonoscopy and histology findings in patients with chronic diarrhea at Dr. Hasan Sadikin Bandung General Hospital, the main referral hospital in West Java. This study aims to determine the features of colonoscopy and histology in patients with chronic diarrhea.Method: This was a cross-sectional, descriptive study from secondary data of colonoscopy examinations at Dr. Hasan Sadikin Hospital General Hospital from 2016 to 2019. The inclusion criteria were patients with chronic diarrhea diagnosis, aged 18 years and over, and completed colonoscopy and biopsy results.Results: A total of 182 subjects with chronic diarrhea were included. Most subjects were women (52%) with an average age of 46 years. The clinical finding at admission was chronic diarrhea without hematochezia (75%). Meanwhile, 52% of colonoscopy lesions were multiple, with the anal-rectum segment (15%) being the most involved. Colonoscopy features mostly hyperemic or edematous lesions (58%). The histopathological result from this study revealed that 59% were non-specific chronic colitis (NSCC). Specific histopathological features were primarily found in malignancies (14%), and inflammatory bowel disease (12%).Conclusion: Chronic diarrhea without hematochezia was the most common objective for referring patients to colonoscopy. The hyperemic mucous lesion was mostly found. Moreover, the NSCC was frequent in histopathological evaluation, followed by malignancies and IBD.

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Clinico-pathological study of colonoscopic biopsies in patients with chronic diarrhea

Cited by 3 publications

References 4 publications

Colonoscopic and Histopathological Findings in Patients with Various Lower Gastrointestinal Symptoms: A Single-Center Experience

Colonoscopic and Histopathological Findings in Patients with Various Lower Gastrointestinal Symptoms: A Single-Center Experience

Histopathological study of endoscopic biopsies of large intestine

Colonoscopy and Histopathologic Features in Chronic Diarrhea Patients at Dr. Hasan Sadikin General Hospital Bandung

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