Clinical Value of Serum Neopterin, Tissue Polypeptide-Specific Antigen and CA19-9 Levels in Differential Diagnosis between Pancreatic Cancer and Chronic Pancreatitis

Talar-Wojnarowska, Renata; Gąsiorowska, Anita; Lekstan, Andrzej; Lampe, Paweł; Małecka‐Panas, Ewa

doi:10.1159/000320693

Cited by 22 publications

(11 citation statements)

References 19 publications

(37 reference statements)

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“…Furthermore, MIC-1 showed a significant difference in levels between PC and CP patients ( P = 0.043), with no noticeable difference observed for NGAL or CA19-9 ( P >0.10). Interestingly, these results are similar to available data from previously published studies evaluating these markers in patient sera (Supplementary Table 4) [8, 9, 21–23]. …”

Section: Discussionsupporting

confidence: 90%

Neutrophil Gelatinase-Associated Lipocalin, Macrophage Inhibitory Cytokine 1, and Carbohydrate Antigen 19-9 in Pancreatic Juice

Kaur¹,

Baine²,

Guha³

et al. 2013

Pancreas

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Objective Pancreatic diseases pose significant diagnostic challenge as signs and symptoms often overlap. We investigated the potential of pancreatic juice neutrophil gelatinase–associated lipocalin (NGAL), macrophage inhibitory cytokine-1 (MIC-1), and carbohydrate antigen 19-9 (CA19-9) to aid in the diagnosis of patients with symptoms suggestive of pancreatic diseases. Methods 105 chronic pancreatitis (CP), pancreatic cancer (PC), and non-pancreatic non-healthy (NPNH, patients with symptoms mimicking pancreatic disease but found to be free of pancreatic pathology) patients underwent endoscopic pancreatic juice collection following secretin-stimulation. NGAL and MIC-1 levels were measured by enzyme-linked immunosorbent assay while CA19-9 was measured by radioimmunoassay. Results NGAL, MIC-1, and CA19-9 were significantly elevated in the pancreatic juice of CP and PC patients as compared to NPNH controls (p<0.034). NGAL appeared most promising in differentiating diseased versus non-diseased pancreata (AUCs=0.88–0.91) while MIC-1 was found to be higher in PC than CP patients (p=0.043). Interestingly, MIC-1 levels in diabetic PC patients were higher than in non-diabetic PC (p=0.030) and diabetic CP patients (p=0.087). CA19-9 showed the least ability to distinguish patient groups (AUCs=0.61–0.76). Conclusions Pancreatic juice NGAL shows potential utility in establishing pancreatic etiology in the context of non-specific symptoms while MIC-1 may aid in differentiating PC from CP.

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Section: Discussionsupporting

confidence: 90%

Neutrophil Gelatinase-Associated Lipocalin, Macrophage Inhibitory Cytokine 1, and Carbohydrate Antigen 19-9 in Pancreatic Juice

Kaur¹,

Baine²,

Guha³

et al. 2013

Pancreas

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“…Therefore, elevated concentrations of neopterin in body fluids reflect cellular immune activation involving T cells and an endogenous release of INF‐γ . Studies have observed increased levels of neopterin in patients with malignant diseases such as lung, breast, and pancreatic cancer . The extent of neopterin elevation depends on tumor type and stage, and neopterin has been proposed as a potential biomarker of cancer diagnosis and prognosis .…”

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confidence: 99%

Interferon‐γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study

Zuo

Tell

Vollset

et al. 2014

Cancer

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BackgroundIt has been reported that interferon-γ (IFN-γ)–induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor of poor prognosis. However, whether baseline levels of these makers are associated with subsequent cancer risk in the general population remains unknown.MethodsWe conducted a prospective analysis of the Hordaland Health Study in 6594 adults without known cancer at baseline who were enrolled between April 1998 and June 1999. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using multivariate Cox proportional hazards regression models adjusted for sex, age, body mass index, smoking status, and renal function.ResultsA total of 971 incident cancer cases (507 men and 464 women) were identified over a median follow-up time of 12 years. Baseline plasma neopterin, KTR and C-reactive protein (CRP) were significantly associated with an increased risk of overall cancer in models adjusted for covariates (P for trend across quartiles = .006 for neopterin, .022 for KTR, and .005 for CRP). The multivariate-adjusted HR (95% CI) per SD increment in similar models were 1.09 (1.03-1.16) for neopterin, 1.07 (1.01-1.14) for KTR, and 1.04 (0.98-1.10) for CRP. The associations between the inflammatory markers and risk of major specific cancer types were also provided.ConclusionsOur findings indicate that plasma neopterin, KTR, and CRP are associated with a significantly increased risk of overall cancer. Our study revealed novel evidence regarding the role of IFN-γ–induced inflammation in human carcinogenesis. Cancer 2014;120:3370–3377. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.Interferon-γ (IFN-γ)–induced inflammatory markers were associated with an increased cancer risk in a cohort of 6594 adults followed for a median of 12 years, revealing evidence for the role of IFN-γ induced inflammation in human carcinogenesis.

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“…With regard to serum CA19-9, its level was dramatically elevated in PC group (253.3 [28] U/mL) at P G 0.001. Prominent IR was found in patients with PC (serum insulin was 17.9 [1.5] HU/mL and HOMA-IR median was 10) compared with diabetic patients (serum insulin was 14.4 [0.8] HU/mL and HOMA-IR median was 6.9) at P G 0.05 and nondiabetic controls (serum insulin was 7.1 [0.4] HU/mL and HOMA-IR median was 1.6) at P G 0.001.…”

Section: Resultsmentioning

confidence: 90%

Clinical Value of Circulating Lipocalins and Insulin-Like Growth Factor Axis in Pancreatic Cancer Diagnosis

El‐Mesallamy¹,

Hamdy²,

zaghloul³

et al. 2013

Pancreas

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Clinical Value of Serum Neopterin, Tissue Polypeptide-Specific Antigen and CA19-9 Levels in Differential Diagnosis between Pancreatic Cancer and Chronic Pancreatitis

Cited by 22 publications

References 19 publications

Neutrophil Gelatinase-Associated Lipocalin, Macrophage Inhibitory Cytokine 1, and Carbohydrate Antigen 19-9 in Pancreatic Juice

Neutrophil Gelatinase-Associated Lipocalin, Macrophage Inhibitory Cytokine 1, and Carbohydrate Antigen 19-9 in Pancreatic Juice

Interferon‐γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study

Clinical Value of Circulating Lipocalins and Insulin-Like Growth Factor Axis in Pancreatic Cancer Diagnosis

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