Clinical Value of Detecting Tumor Endothelial Marker 8 (ANTXR1) as a Biomarker in the Diagnosis and Prognosis of Colorectal Cancer

Abstract

Background Despite the continuous improvements in prevention and detection of colorectal cancer (CRC), there is an urgent need to find a sensitive, specific, and noninvasive biomarker to improve the early diagnosis and prognosis of CRC. We aimed to evaluate the tissue TEM8 expression and the serum TEM8 concentration in CRC patients. Methods The study enrolled 42 CRC patients and 35 controls. Immunohistochemical staining was performed to assess the TEM8 tissue expression, whereas the serum TEM8 concentration was evaluated with the ELISA assay. Results The expression of TEM8 observed in all primary colorectal tumor samples was significantly correlated with the TNM stages and the presence of lymphovascular invasion. The serum TEM8 concentration was significantly higher in CRC patients than in the controls. The TEM8 level was strongly associated with the TNM stage, depth of invasion, and lymph node and distant metastasis. Patients with a high serum TEM8 concentration had a worse overall survival (OS) rate than CRC patients with a low serum TEM8 level. Conclusion TEM8 may serve as a biomarker for the diagnosis of CRC and it has value in predicting the prognosis of patients with CRC.

Quantitative Proteomics Analysis of Differentially Expressed Proteins in Serum of Former Uranium Miners by Isobaric Tags for the Relative and Absolute Quantitation

“…Thus, detection of serum ANTXR1 may serve as a diagnostic biomarker and clinical predictor of CRC. 17 Meanwhile, high ANTXR1 expression was strongly correlated with stromal and immune infiltration in gastric cancer. 18 APOC1, APOC2, APOC3, Orm1, and Orm2 are associated with lipoprotein metabolism.…”

Antibody-drug conjugates: beyond current approvals and potential future strategies

“…Another novel target for ADC development has been TEM8, a transmembrane glycoprotein initially found to be a TEM but more recently also shown to be expressed widely in the tumour stroma across several human tumours [121][122][123]. The TEM8 targeting m825 [124] was developed into an ADC by conjugating it with MMAE via a cleavable linker.…”

Evolving role of seneca valley virus and its biomarker TEM8/ANTXR1 in cancer therapeutics

“…Studies have demonstrated that TEM8/ANTXR1 is enriched in triple negative breast cancer (Xu et al, 2021), prostate cancer (Li et al, 2021a), gastric cancer (Li et al, 2021b;Sun et al, 2021), pancreatic cancer (Alcalá et al, 2019), angiosarcoma (Kusaba et al, 2021(Kusaba et al, ), colon cancer (Ł et al, 2021, and non-small cell lung cancer (NSCLC) (Gong et al, 2021). In multiple tumor types, upregulation of TEM8/ ANTXR1 is a negative prognostic indicator (Li et al, 2021a;Ł et al, 2021;Ding et al, 2021). In triple negative breast cancer, TEM8/ANTXR1, is marker of vasculogenic mimicry, and is associated with poor outcomes (Fernández-Cortés et al, 2019;Xu et al, 2021).…”