Clinical Use of Bone Densitometry

Abstract

Guidelines based on systematic reviews and a cost-effectiveness analysis have suggested that it is worthwhile to measure BMD in white women older than 65 years and perhaps to use risk factors to select younger postmenopausal women for densitometry. Other potential clinical applications of BMD that have not yet been adequately studied include screening men or nonwhite women, monitoring BMD in patients receiving treatment, and using BMD to identify patients who should be evaluated for secondary causes of osteoporosis.

Large Lytic Defects Produce Kinematic Instability and Loss of Compressive Strength in Human Spines

“…We found no significant association between BMD and the strength of the lesioned segment, in agreement with previous in vitro 23,32 and in vivo 33 studies. BMD is a gold standard for estimation of vertebral strength in patients with osteoporosis 34 .…”

“…Our current computational work aims to better understand how the association between abnormal spinal kinematics and vertebral structural damage affects the strength of the pathologic spine. We found no significant association between BMD and the strength of the lesioned segment, in agreement with previous in vitro 23,32 and in vivo 33 studies. BMD is a gold standard for estimation of vertebral strength in patients with osteoporosis 34 .…”

Fracture risk of vertebral bodies after cryosurgery using a miniature cryoprobe: A biomechanical in-vitro analysis on human bones

“…Therefore, no predictive value for individual fracture risk could be made. These results correspond with those of previous investigations [27]. One reason that predictive values could not be calculated is because of the heterogeneity of age, gender, capacity, bone area, bone weight, and density of our specimens.…”

Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes

“…The adjusted difference in heel and forearm BMD by diabetes status ranged from 57–70% of a SD in BMD. Again, this may be clinically relevant as a one SD lower BMD is associated with significant risk of fracture for postmenopausal women [21]. Our results are consistent with two well-designed previous studies which found low hip BMD in individuals with type 1 diabetes compared to controls, though they lacked data on the full spectrum of potential confounders [14;17].…”