Clinical Trial Registration

DeAngelis, Catherine D.; Drazen, Jeffrey M.; Frizelle, Frank; Haug, Charlotte; Hoey, John; Horton, Richard; Kotzin, Sheldon; Lainé, Christine; Marušić, Ana; Overbeke, A. John P.M.; Schroeder, Torben V.; Sox, Hal C.; Weyden, Martin B Van Der

doi:10.1001/archderm.141.1.76

Cited by 31 publications

(7 citation statements)

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“…Preregistration means that researchers outline and register their hypotheses, design, and analysis plan, generally, before data collection (DeAngelis et al, 2005;Laine et al, 2007;Nosek et al,2018). Preregistration prevents researchers from chasing pvalues and selective reporting.…”

Section: Open Research Practicesmentioning

confidence: 99%

Questionable and Open Research Practices: Attitudes and Perceptions among Quantitative Communication Researchers

Bakker

Jaidka

Dorr

et al. 2021

Journal of Communication

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Recent contributions have questioned the credibility of quantitative communication research. While questionable research practices (QRPs) are believed to be widespread, evidence for this belief is, primarily, derived from other disciplines. Therefore, it is largely unknown to what extent QRPs are used in quantitative communication research and whether researchers embrace open research practices (ORPs). We surveyed first and corresponding authors of publications in the top-20 journals in communication science. Many researchers report using one or more QRPs. We find widespread pluralistic ignorance: QRPs are generally rejected, but researchers believe they are prevalent. At the same time, we find optimism about the use of open science practices. In all, our study has implications for theories in communication that rely upon a cumulative body of empirical work: these theories are negatively affected by QRPs but can gain credibility if based upon ORPs. We outline an agenda to move forward as a discipline.

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Section: Open Research Practicesmentioning

confidence: 99%

Questionable and Open Research Practices: Attitudes and Perceptions among Quantitative Communication Researchers

Bakker

Jaidka

Dorr

et al. 2021

Journal of Communication

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“…6. Among other things, the International Committee of Medical Journal Editors (ICMJE) requires all clinical trials must be registered to improve transparency and accountability (DeAngelis et al, 2005). However, none of the trials in this study were registered.…”

Section: Discussionmentioning

confidence: 99%

The quality of reporting of randomized controlled trials of HuatuoZaizao pill for stroke

et al. 2023

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Background: HuatuoZaizao pill (HZP), a Chinese patent medicine, is often used in the treatment of stroke. However, there is still a lack of enough evidence to recommend the routine use of HZP for stroke. This study is aimed at evaluating the quality of reporting of randomized controlled trials (RCTs) on HZP for stroke.Methods: RCTs on HuatuoZaizao pill for stroke were evaluated by using Consolidated Standards of Reporting Trials (CONSORT) guidelines and CONSORT extension criteria on reporting herbal interventions (CONSORT-CHM) guidelines. Microsoft Excel 2007 and SPSS20.0 was used for statistics analyses.Results: Seventeen studies involving 1801 stroke patients were identified. CONSORT-CHM has expanded 24.3% (9/37) items in CONSORT and added a small item. The average scores of CONSORT evaluation is 14.6, while the average scores of the CONSORT-CHM evaluation is 11.6. The central items in CONSORT as eligibility criterion, sample size calculation, primary outcome, method of randomization sequence generation, allocation concealment, implementation of randomization, description of blinding, and detailed statistical methods were reported in 77%, 6%, 100%, 47%, 6%, 6%, 6%, and 94% of trials, respectively. In terms of the CONSORT-CHM, none of the articles reported in detail the dosage form, origin, formula basis and so on of HZP, and only half of studies reported the outcome indicators related to Traditional Chinese Medicine syndromes.Conclusion: The overall report quality of RCT related to HZP is low. HZP still needs to report higher quality RCTs to prove its effectiveness and safety.

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“…These problems require greater transparency; editors should insist that changes to study design and outcomes are reported as stipulated by CONSORT. The International Committee of Medical Journal Editors requires enforcement of prospective registration of clinical trials, including the primary end points, to prevent selective reporting, but this appears to be left at the discretion of authors or peer reviewers. Mandatory supplementary publication of the initial and final trial protocol would allow readers to scrutinize end points themselves and should become more widely adopted.…”

Section: Discussionmentioning

confidence: 99%

Changes to Primary End Points in Randomized Clinical Trials on Immune Checkpoint Inhibitors in Urothelial, Renal Cell, and Lung Cancers

et al. 2023

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Clinical Trial Registration

Abstract: The following full text is a publisher's version. For additional information about this publication click this link.

Cited by 31 publications

References 0 publications

Questionable and Open Research Practices: Attitudes and Perceptions among Quantitative Communication Researchers

Questionable and Open Research Practices: Attitudes and Perceptions among Quantitative Communication Researchers

The quality of reporting of randomized controlled trials of HuatuoZaizao pill for stroke

Changes to Primary End Points in Randomized Clinical Trials on Immune Checkpoint Inhibitors in Urothelial, Renal Cell, and Lung Cancers

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