Clinical Trial Registration

Abstract

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Research Ethics and Reporting Standards at PLoS Neglected Tropical Diseases

“…Any deviation from the trial protocol must be explained. We fully support the position of the ICMJE on trial registration [3]. All trials initiated after July 1, 2005 must be registered prospectively in a publicly accessible registry (before patient recruitment has begun), or they will not be considered for publication.…”

Applying the Risk of Bias Tool in a Systematic Review of Combination Long-Acting Beta-Agonists and Inhaled Corticosteroids for Persistent Asthma

“…We conducted a comprehensive search of various sources for supplemental study information and believe that the low yield was not due to insufficient searching but to a lack of availability of trial protocols and the inherent difficulties in searches of the grey literature. Since the median year of publication for our trials was 2004, recent initiatives such as universal trial registration and the Standard Protocol Items for Randomized Trials (SPIRIT) initiative may improve this in the future [11]; [12].…”

A descriptive analysis of a representative sample of pediatric randomized controlled trials published in 2007

“…Prospective trial registration has been heavily endorsed, and the volume of trials registered appears to be increasing [26-28]. However, trial registration is far from universal, and is perhaps more problematic in pediatric trials.…”