Clinical Study on Measurement Intervals in the Ultrasonographic Gastric Emptying Test for Functional Dyspepsia

Kim, Keum-ji; Jeon, Han Yong; Ko, Seok Jae; Park, Jae-Woo

doi:10.22246/jikm.2020.41.6.1030

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Sample size justification. Previous studies assessing the clinical value of legacy electrogastrography techniques and gastric emptying scintigraphy have been performed with sample sizes ranging from 38 to 72 patients (31,32). Previous studies of BSGM have found significant group-level differences with samples of 43 patients and 43 controls (11).…”

Section: Methodsmentioning

confidence: 99%

Gastric Alimetry Expands Patient Phenotyping in Gastroduodenal Disorders Compared with Gastric Emptying Scintigraphy

Wang,

Foong,

Calder

et al. 2023

Am J Gastroenterol

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Objectives: Gastric emptying testing (GET) assesses gastric motility, however is non-specific and insensitive for neuromuscular disorders. Gastric Alimetry® (GA) is a new medical device combining non-invasive gastric electrophysiological mapping and validated symptom profiling. This study assessed patient-specific phenotyping using GA compared to GET. Methods: Patients with chronic gastroduodenal symptoms underwent simultaneous GET and GA, comprising a 30-minute baseline, 99mTC-labelled egg meal, and 4-hour postprandial recording. Results were referenced to normative ranges. Symptoms were profiled in the validated GA App and phenotyped using rule-based criteria based on their relationships to the meal and gastric activity: i) sensorimotor; ii) continuous; and iii) other. Results: 75 patients were assessed; 77% female. Motility abnormality detection rates were: GET 22.7% (14 delayed, 3 rapid); GA spectral analysis 33.3% (14 low rhythm stability / low amplitude; 5 high amplitude; 6 abnormal frequency); combined yield 42.7%. In patients with normal spectral analysis, GA symptom phenotypes included: sensorimotor 17% (where symptoms strongly paired with gastric amplitude; median r=0.61); continuous 30%; other 53%. GA phenotypes showed superior correlations with GCSI, PAGI-SYM, and anxiety scales, whereas Rome IV Criteria did not correlate with psychometric scores (p>0.05). Delayed emptying was not predictive of specific GA phenotypes. Conclusions: GA improves patient phenotyping in chronic gastroduodenal disorders in the presence and absence of motility abnormalities with increased correlation with symptoms and psychometrics compared to gastric emptying status and Rome IV criteria. These findings have implications for the diagnostic profiling and personalized management of gastroduodenal disorders.

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Section: Methodsmentioning

confidence: 99%

Gastric Alimetry Expands Patient Phenotyping in Gastroduodenal Disorders Compared with Gastric Emptying Scintigraphy

Wang,

Foong,

Calder

et al. 2023

Am J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…techniques and gastric emptying scintigraphy have been performed with sample sizes ranging from 38-72 patients (31,32). Previous studies of BSGM have found significant grouplevel differences with samples of 43 patients and 43 controls (11).…”

Section: Sample Size Justification: Previous Studies Assessing the Cl...mentioning

confidence: 99%

Gastric Alimetry^®improves patient phenotyping in gastroduodenal disorders compared to gastric emptying scintigraphy alone

Wang

Foong

Calder

et al. 2023

Preprint

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Objectives Gastric emptying testing (GET) assesses gastric motility, however is non-specific and insensitive for neuromuscular disorders. Gastric Alimetry (GA) is a new medical device combining non-invasive gastric electrophysiological mapping and validated symptom profiling. This study assessed patient-specific phenotyping using GA compared to GET. Methods Patients with chronic gastroduodenal symptoms underwent simultaneous GET and GA, comprising a 30-minute baseline, 99mTC-labelled egg meal, and 4-hour postprandial recording. Results were referenced to normative ranges. Symptoms were profiled in the validated GA App and phenotyped using rule-based criteria based on their relationships to the meal and gastric activity: i) sensorimotor; ii) continuous; and iii) other. Results 75 patients were assessed; 77% female. Motility abnormality detection rates were: GET 22.7% (14 delayed, 3 rapid); GA spectral analysis 33.3% (14 low rhythm stability / low amplitude; 5 high amplitude; 6 abnormal frequency); combined yield 42.7%. In patients with normal spectral analysis, GA symptom phenotypes included: sensorimotor 17% (where symptoms strongly paired with gastric amplitude; median r=0.61); continuous 30%; other 53%. GA phenotypes showed superior correlations with GCSI, PAGI-SYM, and anxiety scales, whereas Rome IV Criteria did not correlate with psychometric scores (p>0.05). Delayed emptying was not predictive of specific GA phenotypes. Conclusions GA improves patient phenotyping in chronic gastroduodenal disorders in the presence and absence of motility abnormalities with improved correlation with symptoms and psychometrics compared to gastric emptying status and Rome IV criteria. These findings have implications for the diagnostic profiling and personalized management of gastroduodenal disorders.

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Clinical Study on Measurement Intervals in the Ultrasonographic Gastric Emptying Test for Functional Dyspepsia

Cited by 2 publications

References 24 publications

Gastric Alimetry Expands Patient Phenotyping in Gastroduodenal Disorders Compared with Gastric Emptying Scintigraphy

Gastric Alimetry Expands Patient Phenotyping in Gastroduodenal Disorders Compared with Gastric Emptying Scintigraphy

Gastric Alimetry^®improves patient phenotyping in gastroduodenal disorders compared to gastric emptying scintigraphy alone

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Clinical Study on Measurement Intervals in the Ultrasonographic Gastric Emptying Test for Functional Dyspepsia

Cited by 2 publications

References 24 publications

Gastric Alimetry Expands Patient Phenotyping in Gastroduodenal Disorders Compared with Gastric Emptying Scintigraphy

Gastric Alimetry Expands Patient Phenotyping in Gastroduodenal Disorders Compared with Gastric Emptying Scintigraphy

Gastric Alimetry®improves patient phenotyping in gastroduodenal disorders compared to gastric emptying scintigraphy alone

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Gastric Alimetry^®improves patient phenotyping in gastroduodenal disorders compared to gastric emptying scintigraphy alone