2009
DOI: 10.1007/s00701-009-0425-z
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Abstract: Poor cognitive function was common and occurred in up to 43.6% of the patients, with the verbal and behavioural memory aspects predominantly affected. We did not find a significant association between cholinergic dysfunction and cognitive dysfunction. Organization of future drug trials and cognitive rehabilitation should take into account the association between frontal lobe dysfunction and chronic hydrocephalus.

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Cited by 28 publications
(15 citation statements)
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“…26 Abnormalities in cognitive function are common after surgery for aneurysmal SAH, even among patients with a good functional outcome, and can occur in up to 44% of survivors. [27][28][29] This academically funded study was done without any industry support using generic medications and weakness would include lack of on-site trial monitoring due to restraints in funding. We have not incorporated daily blood pressure data in the trial design.…”
Section: Discussionmentioning
confidence: 99%
“…26 Abnormalities in cognitive function are common after surgery for aneurysmal SAH, even among patients with a good functional outcome, and can occur in up to 44% of survivors. [27][28][29] This academically funded study was done without any industry support using generic medications and weakness would include lack of on-site trial monitoring due to restraints in funding. We have not incorporated daily blood pressure data in the trial design.…”
Section: Discussionmentioning
confidence: 99%
“…patterns of cognitive impairments post-SAH vary [13] though most report significant impairment across domains [14][15][16] . These inconsistencies are likely due to differing samples, with fewer cognitive deficits reported when participants with unfavourable neurological outcome, greater age ( 1 70 years) and aphasia are exclud ed [13] .…”
mentioning
confidence: 99%
“…Cognitive impairments post-SAH affect memory [15][16][17][18] , executive function, language, visual perception, attention, and motor and psychomotor speed [8,14,17] . While cognitive deficits have been documented 5 years post-SAH [19] , testing time varied within studies from 1 day to 5 years post-SAH [19,20] , none are populationbased, and most exclude the very old [21] and those with severe SAH [16] .…”
mentioning
confidence: 99%
“…22,27 Abnormalities in cognitive function are common after surgery/intervention for aneurysmal SAH, even among patients with a good functional outcome, and can occur in ≤44% of survivors. 28,29 Cognitive assessments would be of interest to investigate in future neuroprotective clinical trials for aneurysmal SAH.…”
Section: Discussionmentioning
confidence: 99%
“…После операции/вмеша-тельства по поводу аневризматического САК часто развиваются нарушения когнитивной функции, даже среди пациентов с благоприятным функциональным исходом, и встречаются у ≤44% выживших пациентов [28,29]. В связи с этим в будущих клинических испыта-ниях нейропротекторов при аневризматическом САК следует проводить оценку когнитивной функции.…”
Section: ■ обсуждениеunclassified