Clinical study on autosomal dominant polycystic kidney disease among North Tunisians

Hajji, M.; Barbouch, S.; Hedri, H.; Kâaroud, H.; Abderrahim, E.; Goucha, R.; Hamida, F. Ben; Gorsane, I.; Abdallah, T. Ben

doi:10.4103/1319-2442.252908

Cited by 7 publications

(9 citation statements)

References 1 publication

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“…We assessed the demographic, diagnostic and therapeutic characteristics of ADPKD patients in Nephrology clinic at KATH, Kumasi. In line with earlier studies, we found that the disease mostly presented in patients aged 31 years and above, with the highest occurrence within ages 31 to 40 years [1,11,12]. This is consistent with existent literature that ADPKD often occurs in adults over 30 years of age [2,13,14].…”

Section: Discussionsupporting

confidence: 93%

“…In accordance with Hajji et al, [1], the drugs reported in this study are designed to manage the symptoms, complications and comorbidities associated with the disease. According to Pei et al, [17], the development of hypertension indicates disease progression and must be managed ideally with blood pressure target of 130/80 mm/Hg.…”

Section: Discussionmentioning

confidence: 91%

“…The activation of RAAS and sympathetic nervous system are the predominant causes of hypertension in ADPKD. Left ventricular hypertrophy (LVH) also causes high BP and increases cardiovascular risk in this condition [1]. Therefore, early detection and treatment of hypertension could hinder cyst development and cardiovascular complications [18].…”

Section: Discussionmentioning

confidence: 99%

“…Autosomal Dominant Polycystic Kidney Disease (ADPK D) is the most common form of hereditary kidney disease that mostly manifests during adulthood [1]. Characterized by the formation and growth of multiple cysts, ADPKD distorts kidney structure and function and ultimately results in End Stage Kidney Damage (ESRD) [2].…”

Section: Introductionmentioning

confidence: 99%

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Demographic, diagnostic and therapeutic characteristics of autosomal dominant polycystic kidney disease in Ghana

et al. 2021

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Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the commonest of the hereditary kidney diseases and mostly ensues in utero with signs delayed until after several decades. This study assessed the demographic, diagnostic (clinical and biochemical features) and therapeutic patterns among ADPKD patients who attended the nephrology unit of Komfo Anokye Teaching Hospital (KATH) from 2007 to 2018. Methods This cross-sectional retrospective analysis of ADPKD patient records was conducted at the nephrology unit of KATH in October 2020. The records of 82 ADPKD was used for this study. Demographic, clinical, biochemical, ultrasonographic and therapeutic data was obtained, organized and analyzed with Statistical Package for the Social Sciences (SPSS). Results ADPKD was most prevalent in people within the ages of 31–40 years (25.6 %), with a male (52.4 %) preponderance. The most common clinical features presented were flank pain (30.5 %) and bipedal swelling (18.3 %). Hypertension (42.7 %), urinary tract infections (UTIs) (19.5 %), and anemia (13.4 %) were the most common complications reported. Average level of HDL-c was higher in females (1.7) than in males (1.2) (p = 0.001). Hematuria (34 %) and proteinuria (66 %) were among the biochemical derangements presented. About 81.7 % had CKD at diagnosis with the majority in stages 1 (27.0 %), 3(23.2 %) and 5 (20.3 %). Poor corticomedullary differentiation was observed in 90.2 % of participants and increased echogenicity was observed in 89.0 % of the participants. Estimated GFR (eGFR) correlated positively with echotexture (r = 0.320, p = 0.005) and negatively with CMD (r= -0.303, p = 0.008). About 95.1 % of patients were on conservative therapy including: 73.2 %, 52.4 %, 22.0 %, 13.4 %, 8.5 % on Irebesartan/Lisinopril, Nifecard XL, Hydralazine, Methyldopa and Bisoprolol respectively for hypertension; 26.8 and 3.7 % on Gliclazide and Metformin respectively for Type 2 diabetes mellitus; 25.6 %, 24.4 and 18.3 % on CaCO3, fersolate and folic acid respectively as nutrient supplements with 4.9 % of participants on renal replacement therapy (RRT). Conclusions ADPKD occurs in people aged ≥ 31 years with a higher male preponderance. Clinical features include flank and abdominal pain, bipedal swelling, headache, amongst others. Uremia, hematuria, proteinuria, decreased eGFR, were the common biochemical derangements reported with higher severity detected in men. The therapeutic interventions mostly involved conservative therapy to manage symptoms and other comorbid conditions and rarely renal replacement therapy (RRT).

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Demographic, diagnostic and therapeutic characteristics of autosomal dominant polycystic kidney disease in Ghana

et al. 2021

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“…We identified an additional 20 eligible articles through our further search strategy described above, which resulted in a total of 49 eligible articles (a total of 9396 patients with ADPKD). 7 - 12 , 14 , 17 - 58 The chance-corrected agreement between 2 independent reviewers for full-text eligibility was excellent (κ = 0.86).…”

Section: Resultsmentioning

confidence: 93%

Stone Prevalence in Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis

Kalatharan

Grewal

Nash

et al. 2020

Can J Kidney Health Dis

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Background: It is uncertain how often patients with autosomal dominant polycystic kidney disease (ADPKD) develop kidney stones. Objective: To review English-language studies reporting the incidence and prevalence of stones and stone interventions in adults with ADPKD. Design: Systematic review and meta-analysis. Setting: Any country of origin. Patients: Adult patients with ADPKD. Measurements: Incidence or prevalence of kidney stones and stone interventions. Methods: We reviewed 1812 citations from bibliographic databases, abstracted data from 49 eligible studies, and assessed methodological quality in duplicate. In some studies, the proportion of adults with ADPKD with the outcome were compared to adults without ADPKD; for these studies, prevalence risk ratios were calculated and pooled using a random effects model. Results: We identified 49 articles that met our review criteria. The methodological quality of many studies was limited (scores ranging from 2 to 14 out of 22, with a higher score indicating higher quality). No study clearly reported stone incidence, and in the cross-sectional studies, the definition of stones was often unclear. The prevalence of stones ranged from 3% to 59%, and a prevalence of stone interventions ranged from 1% to 8%; the average patient age at the time of assessment ranged from 26 to 61 years across the studies. Two studies reported a nonstatistically significant higher stone prevalence in patients with ADPKD compared to unaffected family members. Compared to unaffected family members, patients with ADPKD had a higher prevalence of kidney stones (6 cross-sectional studies; unadjusted prevalence ratio: 1.8; 95% confidence interval: 1.3 to 2.6; P = .0007; test for heterogeneity: I2 = 0%, P = .8). Limitations: Studies were limited to articles published in English. Conclusions: The prevalence of kidney stones and stone interventions in adults with ADPKD remains uncertain. Future studies of higher methodological quality are needed to better characterize the incidence and prevalence of kidney stones in patients with ADPKD. Trial registration: We did not register the protocol for this systematic review.

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Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases

Olesen

Fenton

2021

Nat Rev Nephrol

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Clinical study on autosomal dominant polycystic kidney disease among North Tunisians

Cited by 7 publications

References 1 publication

Demographic, diagnostic and therapeutic characteristics of autosomal dominant polycystic kidney disease in Ghana

Demographic, diagnostic and therapeutic characteristics of autosomal dominant polycystic kidney disease in Ghana

Stone Prevalence in Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis

Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases

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