Clinical significance of urinary liver-type fatty acid binding protein at various stages of nephropathy

Viswanathan, Vijay; Sivakumar, S; Sekar, Vidhushini; Umapathy, Dhamodharan; Kumpatla, Satyavani

doi:10.4103/0971-4065.145097

Cited by 26 publications

(22 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Urinary L-FABP levels were significantly increased in macroalbuminuric patients compared with microalbuminuric and currently normoalbuminuric patients [ 46 ]. In one study from type 2 diabetes mellitus patients, elevated levels of urinary L-FABP were evident from the microalbuminuric stage, indicating tubular damage at the early stage of DN [ 50 ]. According to this study, urinary excretion of L-FABP levels in the microalbuminuric group was significantly correlated with systolic BP, fasting plasma glucose, and HbA1c, which indicated that urinary L-FABP could be most sensitive marker for detecting glomerular and tubular dysfunction at the early stage of DN [ 50 ].…”

Section: Liver-type Fatty Acid Binding Proteinmentioning

confidence: 99%

Urinary Markers of Tubular Injury in Early Diabetic Nephropathy

Fiseha

Tamir

2016

International Journal of Nephrology

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is a common and serious complication of diabetes associated with adverse outcomes of renal failure, cardiovascular disease, and premature mortality. Early and accurate identification of DN is therefore of critical importance to improve patient outcomes. Albuminuria, a marker of glomerular involvement in early renal damage, cannot always detect early DN. Thus, more sensitive and specific markers in addition to albuminuria are needed to predict the early onset and progression of DN. Tubular injury, as shown by the detection of tubular injury markers in the urine, is a critical component of the early course of DN. These urinary tubular markers may increase in diabetic patients, even before diagnosis of microalbuminuria representing early markers of normoalbuminuric DN. In this review we summarized some new and important urinary markers of tubular injury, such as neutrophil gelatinase associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver-type fatty acid binding protein (L-FABP), N-acetyl-beta-glucosaminidase (NAG), alpha-1 microglobulin (A1M), beta 2-microglobulin (B2-M), and retinol binding protein (RBP) associated with early DN.

show abstract

Section: Liver-type Fatty Acid Binding Proteinmentioning

confidence: 99%

Urinary Markers of Tubular Injury in Early Diabetic Nephropathy

Fiseha

Tamir

2016

International Journal of Nephrology

View full text Add to dashboard Cite

show abstract

“…Several studies on adult patients with diabetes have consistently supported that L-FABP is an early marker for tubular injury which is in agreement with the current study. Viswanathan et al [24] and Panduru et al [25] found that L-FABP was an independent predictor of progression of DN. Kamijo-Ikemori et al [26] and Nielsen et al [13] concluded that high levels of urinary L-FABP could predict DN.…”

Section: Discussionmentioning

confidence: 99%

Urinary liver-type fatty acid-binding protein as a Marker for Early Diagnosis of Diabetic Nephropathy in Type 1 Diabetic Children.

AbuShady

Fathy

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: Renal failure and premature mortality are fatal prognosis of diabetic nephropathy. To improve patient outcome, early diagnosis of diabetic nephropathy is necessary. The study was designed to evaluate urinary liver-type fatty acid binding protein (L-FABP), as an early biomarker of tubulointerstitial injury, and its association with the clinical characteristics of type 1 diabetic children.Methods: Fifty randomly selected patients with type 1 diabetes mellitus (DM) attending the diabetes outpatient clinic of Ain Shams University Children’s Hospital were included in the study. 50 age and sex-matched healthy subjects were enrolled as controls. Urinary L-FABP, 24 h urine albumin, hemoglobin A1c (HbA1c), serum creatinine, and lipid profile were measured.Results: Diabetic subjects had higher mean urinary L-FABP than controls (p<0.05). In microalbuminuric diabetic subjects, the mean urinary L-FABP was detected to be significantly higher than that in normoalbuminuric diabetic subjects, and significantly higher values of the mean urinary L-FABP were detected in the microalbuminuric and the normoalbuminuric subjects than the controls (p<0.05). Multiple linear regression analysis showed that duration of DM and HbA1c was the main predictors of urinary L-FABP in diabetic subjects.Conclusion: In patients with childhood-onset T1D, urinary L-FABP may be used as an indicator of renal injury in early stages of nephropathy, even in the normoalbuminuric state.

show abstract

“…The occurrence of tubular damage in the early stages of diabetic nephropathy has been reported in various studies done on urinary biomarkers in diabetic patients. [12][13][14][15][16] In our study we tested urinary periostin as a biomarker to diagnose renal injury in type 2 diabetic subjects. Periostin expression in kidney and its detection in urine during renal injury has been demonstrated in very few studies.…”

Section: Discussionmentioning

confidence: 99%

Urinary Periostin as an Early Predictor of Renal Injury in Diabetic Kidney Disease: A Tertiary Centre Experience

Patel¹,

Sachan²,

Pushkar³

et al. 2019

IJMEDPH

View full text Add to dashboard Cite

Introduction: Early and accurate detection of onset of diabetic nephropathy is crucial for a timely intervention and for improving outcomes in the management of diabetic nephropathy. There is a need of new biomarkers to predict the onset of nephropathy earlier than the conventional markers. The aim of this study was to measure the association of urinary periostin level in type 2 subjects and healthy controls and to evaluate its predictive value to diagnose renal injury. Methods: This was a cross sectional study in which urine samples were collected from 50 healthy controls and 360 type 2 diabetic patients. The diabetic cases were further grouped as; normoalbuminuria (n=95), microalbuminuria (n=130) and macroalbuminuria (n=135). The urinary levels of periostin was measured by using an enzyme-linked immunosorbent assay kit. Observations: Urinary periostin levels were found to be significantly elevated in all the diabetic patients compared to the controls. In multivariate regression analysis increased urine periostin level significantly correlated with aging, high albuminuria and decline of eGFR. For differentiating normalbuminuria, microalbumiuria and macroalbuminuria the best selected cutoff values with optimum sensitivity and specificity were >2.11, 2.74 and 7.81 respectively with predicted sensitivity and specificity of 88% and 100%, 98.1% and 66.7% and 100% and 69.9% respectively. Therefore, urinary periostin demonstrated moderate to high sensitivity and specificity for diagnosing diabetic nephropathy. Conclusion: Increased levels of urinary periostin significantly correlated with aging, high albuminuria, declinement of eGFR and can be detected in the urine of the patients with type 2 diabetes before the onset of significant albuminuria. Urinary periostin excretion may be used as an early biomarker of renal injury.

show abstract

Clinical significance of urinary liver-type fatty acid binding protein at various stages of nephropathy

Cited by 26 publications

References 17 publications

Urinary Markers of Tubular Injury in Early Diabetic Nephropathy

Urinary Markers of Tubular Injury in Early Diabetic Nephropathy

Urinary liver-type fatty acid-binding protein as a Marker for Early Diagnosis of Diabetic Nephropathy in Type 1 Diabetic Children.

Urinary Periostin as an Early Predictor of Renal Injury in Diabetic Kidney Disease: A Tertiary Centre Experience

Contact Info

Product

Resources

About