Clinical significance of the serum miR-455-5p expression in patients with neonatal sepsis

Abstract

Sepsis is a systemic inflammatory response caused by infection and is a major cause of neonatal death. This study explored the miR-455-5p in neonatal sepsis, and further investigated the diagnostic and prognostic value of miR-455-5p in neonatal sepsis (NS). The levels of serum miR-455-5p in 88 healthy controls and 90 NS patients were examined by quantitative real-time polymerase chain reaction (qRT-PCR). Pearson correlation coefficient was used to evaluate the correlation between miR-455-5p and clinical features. Receiver operating characteristic (ROC) curve analysis was performed for the diagnostic evaluation on miR-455-5p. The prognostic value of miR-455-5p in NS was analyzed by Kaplan-Meier survival curve and multivariate Cox regression. The expression of serum miR-455-5p in NS patients was highly expressed in comparison to healthy controls (P < 0.001), and the level of miR-455-5p was positively correlated with white blood cell count (WBC) and other clinical characteristics (P < 0.01). The AUC value of ROC curve was 0.895, suggesting that miR-455-5p had diagnostic value for NS. Survival analysis illustrated that patient with high miR-455-5p expression had poor prognosis (log rank P = 0.015), and miR-455-5p may be a potential prognostic marker for NS (HR = 3.454, 95% CI = 1.165-10.234, P = 0.025). The expression of miR-455-5p had the ability to distinguish NS from healthy people, and highly expressed miR-455-5p was associated with poor prognosis in NS patients.

Altered microRNA expression in severe COVID-19: potential prognostic and pathophysiological role

“…Both hsa-miR-200b and hsa-miR-455 were found upregulated in pneumonia [66]. hsa-miR-455-5p was overexpressed in patients with neonatal sepsis compared to healthy controls and highly expressed miR-455-5p was associated with poor prognosis [67]. miR-455-5p was upregulated in rabies virus infection in vitro , decreased SOCS3 expression and increased STAT3 activity resulting in enhanced viral replication and the production of interleukin-6 (IL-6) [68].…”

MiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling

“…For example, miR-455-5p upregulation influences retinol absorption in a lung hypoplasia model by regulating STRA6 [ 47 ]. Moreover, miR-455-5p is considered to be a diagnostic and prognostic marker for neonatal sepsis [ 20 ]. A previous study has indicated that rno-miR-455-5p contributes to the proliferation of ESCs that are treated with TGF-β for establishing an IUA cell model [ 22 ].…”

“…Recently, miR-455-5p has attracted increasing attention and has been reported to participate in multiple disorders. For example, miR-455-5p upregulation is related to the poor prognosis of patients with neonatal sepsis [ 20 ]. Moreover, miR-455-5p inhibits the proliferation and migration of vascular smooth muscle cells [ 21 ].…”