Clinical significance of serum total sialic acid in cholangiocarcinoma

Wongkham, Sopit; Bhudhisawasdi, Vajarabhongsa; Chau-in, Siri; Boonla, Chanchai; Muisuk, Kanha; Kongkham, Supranee; Wongkham, Chaisiri; Boonsiri, Patcharee; Thuwajit, Peti

doi:10.1016/s0009-8981(02)00371-6

Cited by 23 publications

(16 citation statements)

References 28 publications

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“…Based on the ROC curve analysis, a cut-off point of 1.75 mmol/L provided a satisfactorily high sensitivity, specificity and accuracy of above 80 % for the differential diagnosis of CCA from HCC. The data of the present study are in agreement with those previously reported which described an increase in serum TSA in patients with CCA [10,15] . Thus, serum TSA would be a useful marker, particularly in conjunction with radiological studies such as ultrasonography or CT scan, for the detection of CCA in patients presenting with clinical features of liver mass and jaundice.…”

Section: Discussionsupporting

confidence: 94%

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Kongtawelert

Tangkijvanich²,

Ongchai³

et al. 2003

WJG

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Section: Discussionsupporting

confidence: 94%

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Kongtawelert

Tangkijvanich²,

Ongchai³

et al. 2003

WJG

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“…A decrease in serum sialoglycoconjugate degradation and/or an altered clearing of these glycoconjugates by the liver could also account for the elevation of serum sialic acids [ 63 ]. The increased serum sialic acid concentration was directly correlated to an increase in the concentration and the degree of sialylation of tumor secreted products such as alkaline phosphatase, MUC5AC mucin and CA19–9 which are sialoglycoconjugates, as reported by Wongkham et al [ 197 ]. It is speculated that serum MU5AC mucin and antigen CA19–9 are related to the increased amount of white blood cells as well as secretion of cytokines and glycoproteins from immune cells in serum of cancer patients; one possible explanation for the elevation of serum TSA [ 197 ].…”

Section: Putative Mechanisms For the Serum/plasma Sialylation Changesmentioning

confidence: 57%

“…In certain cancers, increased activity of sialyltransferase and the high turnover of tumor cells might lead to spontaneous shedding of aberrant sialic acid-containing cell surface glycoconjugates into the circulation and cause the high sialic acid concentration in the serum [ 196 ]. In one study, tumor tissue TSA/TP was found to be significantly higher than serum TSA /TP supporting the hypothesis of an enhancement in tumor sialoglycoconjugate biosynthesis and shedding being the cause of an increase in serum sialic acid content [ 197 ]. A decrease in serum sialoglycoconjugate degradation and/or an altered clearing of these glycoconjugates by the liver could also account for the elevation of serum sialic acids [ 63 ].…”

Section: Putative Mechanisms For the Serum/plasma Sialylation Changesmentioning

confidence: 93%

Serum sialylation changes in cancer

2018

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Cancer is a major cause of death in both developing and developed countries. Early detection and efficient therapy can greatly enhance survival. Aberrant glycosylation has been recognized to be one of the hallmarks of cancer as glycans participate in many cancer-associated events. Cancer-associated glycosylation changes often involve sialic acids which play important roles in cell-cell interaction, recognition and immunological response. This review aims at giving a comprehensive overview of the literature on changes of sialylation in serum of cancer patients. Furthermore, the methods available to measure serum and plasma sialic acids as well as possible underlying biochemical mechanisms involved in the serum sialylation changes are surveyed. In general, total serum sialylation levels appear to be increased with various malignancies and show a potential for clinical applications, especially for disease monitoring and prognosis. In addition to overall sialic acid levels and the amount of sialic acid per total protein, glycoprofiling of specific cancer-associated glycoproteins, acute phase proteins and immunoglobulins in serum as well as the measurements of sialylation-related enzymes such as sialidases and sialyltransferases have been reported for early detection of cancer, assessing cancer progression and improving prognosis of cancer patients. Moreover, sialic-acid containing glycan antigens such as CA19–9, sialyl Lewis X and sialyl Tn on serum proteins have also displayed their value in cancer diagnosis and management whereby increased levels of these factors positively correlated with metastasis or poor prognosis.

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“…It has been established that the SA concentrations are elevated in patients suffering from various diseases and pathological conditions [8][9][10][11][12]. Still, the serum SA in lambs with WMD has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Serum Selenium, Vitamin E, and Sialic Acids Concentrations in Lambs with White Muscle Disease

Değer

Mert

et al. 2007

Biol Trace Elem Res

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The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. Fifteen lambs with WMD and ten control animals were used as research materials. Blood samples were collected from both groups before- and 1 month after treatment for Se analysis by fluorimetry, whereas vitamin E and sialic acid were measured by HPLC and spectrophotometry, respectively. Compared to controls, in the diseased animals, there was a significant increase of serum total sialic acid (TSA) and LBSA, together with significant decreases of serum Se and vitamin E concentrations (p < 0.001). One month after treatment, a reversal of trend was observed with decreases of TSA and LBSA and increases of Se and vitamin E concentrations. The TSA and LBSA levels, however, remained significantly higher than those of the controls, p < 0.05 and 0.001, respectively. The Se and vitamin E concentrations of the treated animals were the same as those of controls. This is the first study on total and LBSA concentrations in lambs with WMD, showing that these markers can be used in the prognosis of the disease.

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Clinical significance of serum total sialic acid in cholangiocarcinoma

Cited by 23 publications

References 28 publications

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Serum sialylation changes in cancer

Serum Selenium, Vitamin E, and Sialic Acids Concentrations in Lambs with White Muscle Disease

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