2018
DOI: 10.1016/j.neo.2018.03.002
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Abstract: PTEN loss has been associated with poorer prognosis in many solid tumors. However, such investigation in lymphomas is limited. In this study, PTEN cytoplasmic and nuclear expression, PTEN gene deletion, and PTEN mutations were evaluated in two independent cohorts of diffuse large B-cell lymphoma (DLBCL). Cytoplasmic PTEN expression was found in approximately 67% of total 747 DLBCL cases, more frequently in the activated B-cell–like subtype. Nuclear PTEN expression was less frequent and at lower levels, which s… Show more

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Cited by 51 publications
(44 citation statements)
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“…However, homozygote deletion of PTEN or activating mutation in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) was not associated with increased expression of PD-L1 in TNBCs [78]. In the diffuse large B-cell lymphoma, loss of cytoplasmic PTEN was associated with TP53 mutations higher PTEN-targeting microRNA expression and lower mean level of PD-L1 expression whereas PTEN deletion/mutation and expression of p-AKT, PI3K, or nucleoplasmic-PTEN had no association with PD-L1 expression [11].…”
Section: Pten Deficient Tumors Do Not Necessarily Have a Better Respomentioning
confidence: 98%
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“…However, homozygote deletion of PTEN or activating mutation in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) was not associated with increased expression of PD-L1 in TNBCs [78]. In the diffuse large B-cell lymphoma, loss of cytoplasmic PTEN was associated with TP53 mutations higher PTEN-targeting microRNA expression and lower mean level of PD-L1 expression whereas PTEN deletion/mutation and expression of p-AKT, PI3K, or nucleoplasmic-PTEN had no association with PD-L1 expression [11].…”
Section: Pten Deficient Tumors Do Not Necessarily Have a Better Respomentioning
confidence: 98%
“…Loss of PTEN functions due to genetic aberration or epigenetic silencing has been related to malignant transformation, progression, chemotherapy response and survival in several cancers [8][9][10][11]. PI3K pathway alterations were identified in 44% of the 60,991 solid tumors and PTEN (9.4%) was the second frequently altered gene after PI3K (13.3%) [12].…”
Section: Background: Tumour Suppressive Functions Of Pten and Prevalementioning
confidence: 99%
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“…For example, PTEN is a tumor suppressor and mutated in a large number of cancers at high frequency, and PTEN deletion, mutation, and loss of PTEN expression were of clinical significance in de novo DLBCL. 48 As a result, we investigated the prognostic performance of PTEN in OSdlbcl at both RNA and DNA levels, and the results showed that PTEN is an independent favorable prognostic factor for OS at the RNA level (HR = 0.67, P < .05) (Figure 2A), while PTEN mutation is the independent prognostic factor for poorer survival in DLBCL (HR = 0.11, P = .04) ( Figure 2B). In addition, the gene expression variation between DLBCL cases with wildtype (Wt) and mutation (Mut) gene types can also be investigated in OSdlbcl ( Figure 2C).…”
Section: Determination Of the Prognostic Value Of Dna Mutation In Omentioning
confidence: 98%