Clinical Significance of Lymph Node Metastasis of Thyroid Papillary Carcinoma Located in One Lobe

Ito, Yasuhiro; Jikuzono, Tomoo; Higashiyama, Takuya; Asahi, Shuji; Tomoda, Chisato; Takamura, Yuuki; Miya, Akihiro; Kobayashi, Kaoru; Matsuzuka, Fumio; Kuma, Kanji; Miyauchi, Akira

doi:10.1007/s00268-006-0211-5

Cited by 178 publications

(140 citation statements)

References 23 publications

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“…A previous study (23) even suggested that patients without high-risk factors of thyroid carcinoma should not immediately undergo surgery. Neck lymph node metastasis does not affect the PTMC prognosis (24), even with re-operation following recurrence. A previous study (25) reported that the recurrence during prophylactic neck lymph nodes dissection is higher compared to those not undergoing surgery.…”

Section: Discussionmentioning

confidence: 90%

Outcome of papillary thyroid microcarcinoma: Study of 1,990 cases

Zhang

Wei

et al. 2015

Molecular and Clinical Oncology

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Abstract. The present study examines the requirement of prophylactic neck node dissection in papillary thyroid microcarcinoma (PTMC) patients by analyzing high-risk factors of neck lymph node metastasis in PTMC. The clinical pathological data was a review of 1,990 patients diagnosed between January 2013 and January 2014. The data included information on patient gender, age, tumor size, multifocal, tumor pathological staging, bilateral thyroid cancer, the subtypes, BRAF V600E mutation, human telomerase reverse transcriptase (hTERT), extrathyroidal invasion and neck lymph node metastasis. The univariate analysis (χ 2 test) showed that a number of factors were significantly associated with neck lymph node metastasis in PTMC (P<0.05): Male gender, aged <45 years, extrathyroidal invasion, bilateral thyroid cancer, various subtypes (package type, follicular variant, diffuse sclerosing variant, eosinophils, tall cell and column variant), BRAF V600E mutation-positive, hTERT mutation-positive, pt3/4 and multifocality. The multivariate analysis (regression binary logistic) showed that the male gender, <45 years, tumor size >5 mm, extrathyroidal invasion, bilateral thyroid tumors, multifocality, BRAF V600E mutation-positive, hTERT mutation-positive and pt3/4 are associated with the neck lymph node metastasis in PTMC (P<0.05). These paired analysis results show that the subtypes of PTMC with tumor size >5 mm is more common than the specific types of PTMC in which the tumor is ≤5 mm in neck lymph node metastasis. The neck lymph node metastasis incidence of the >45 years age group patients without high-risk factors in PTMC is 8.13 and 6.80%, respectively. In conclusion, PTMC patients with high-risk factors only are recommended to undergo a prophylactic lymph node dissection.

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Section: Discussionmentioning

confidence: 90%

Outcome of papillary thyroid microcarcinoma: Study of 1,990 cases

Zhang

Wei

et al. 2015

Molecular and Clinical Oncology

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“…Also, these patients are more likely to have lateral LN metastases. Initial CND prevents central recurrence of the malignant disease [25][26][27]. Re-operations in central compartment, in comparison to initial surgery, more often lead to persistent hypoparathyroidism and RLN injury [16,[28][29][30].…”

Section: Resultsmentioning

confidence: 99%

Lymphatic drainage, regional metastases and surgical management of papillary thyroid carcinoma arising in pyramidal lobe – a single institution experience

et al. 2014

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“…node metastasis (undetectable on imaging studies but detectable on pathological examination) increased with tumor size [20][21][22]. Other research groups have investigated the relationship between lymph node metastasis and patient age.…”

Section: Prognostic Significance Of Age In Clinical Ptcmentioning

confidence: 99%

Prognosis and growth activity depend on patient age in clinical and subclinical papillary thyroid carcinoma [Review]

et al. 2014

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Abstract. In this review, we focused on the patient age as an indicator of tumor growth and prognostic significance in both clinical papillary thyroid carcinoma (PTC) and subclinical papillary microcarcinoma (PMC: PTC ≤ 1 cm). In clinical PTC, young age (< 30 years) and old age (≥ 60 years) significantly affected the disease-free survival of patients, and old age was a strong predictor of carcinoma death. In contrast, in subclinical PMC, growth activity significantly decreased with patient age, and young age (< 40 years) was an independent predictor of carcinoma growth, indicating that old patients with subclinical PMC are the best candidates for observation without immediate surgery. Taken together, our findings indicate that the role of patients' age as an indicator of tumor growth differs significantly between clinical PTC and subclinical PMC.

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Clinical Significance of Lymph Node Metastasis of Thyroid Papillary Carcinoma Located in One Lobe

Abstract: Central node metastasis independently predicts a worse DFS for patients with papillary carcinoma larger than 1 cm.

Cited by 178 publications

References 23 publications

Outcome of papillary thyroid microcarcinoma: Study of 1,990 cases

Outcome of papillary thyroid microcarcinoma: Study of 1,990 cases

Lymphatic drainage, regional metastases and surgical management of papillary thyroid carcinoma arising in pyramidal lobe – a single institution experience

Prognosis and growth activity depend on patient age in clinical and subclinical papillary thyroid carcinoma [Review]

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