Clinical significance of anti-DFS70 in immunoinflammatory rheumatic diseases (review)

Abstract

The relevance of the problem of immunoinflammatory rheumatic diseases (IIRD) for modern medicine is determined by their high prevalence in the population, the difficulty of early diagnosis, the rapid development of disability and poor life prognosis. Recent data on the significance of anti-DFS70 have opened up new possibilities for optimizing the step-by-step diagnosis of IIRD. The detection of these antibodies can help in the interpretation of a positive result for antinuclear antibodies (ANA) by indirect immunofluorescence assay on HEp-2 cells (IIFA-HEp-2) in the absence of autoantibodies specific for IIRD. Detection of anti-DFS70 in antinuclear factor (ANF) seropositive patients without clinical and/or serological markers characteristic of a certain disease from the IIRD group can be considered as a potential marker that excludes this group of diseases.

The Role of Anti-DFS70 in the Diagnosis of Systemic Autoimmune Rheumatic Diseases

“…According to the results of various studies, a negative association has been observed between isolated anti-DFS70 antibodies and SLE and other SARDs [32], in which these autoantibodies are found in isolation in less than 1% of patients (except for this figure in children with SLE, where it was 1.8%-though these data are based on the results of just one study) (Table 3) [33]. It can be stated that we observe a lower frequency of anti-DFS70 occurrence in this patient cohort compared to healthy individuals.…”