Clinical significance of ANCA positivity in patients with IgA vasculitis: a retrospective monocentric study

Kim, Jae Yeon; Choi, Hyang Suk; Kim, Minyoung Kevin; Lee, Soo Bin; Park, Yong Bum; Lee, Sang Won

doi:10.1007/s00296-019-04397-3

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…In a study including patients with IgA vasculitis, the so-called Henoch-Schönlein purpura, ANCA positivity - pANCA only - was seen in 5.8% of the patients, affecting older patients with more significant pulmonary and neurological involvement 7 . It has been posited that ANCA is the outcome of a cytokine storm that might affect some patients, leading to the release of "antigens" recognized by ANCA.…”

Section: Discussionmentioning

confidence: 99%

“…It has been posited that ANCA is the outcome of a cytokine storm that might affect some patients, leading to the release of "antigens" recognized by ANCA. Since pulmonary and neurological involvement are uncommon in IgA vasculitis, the authors assumed ANCA might have a role in the pathogenesis of this condition 7 . The patients included in our study did not meet the criteria for IgA vasculitis.…”

Section: Discussionmentioning

confidence: 99%

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IgA nephropathy in patients with serum anti-neutrophil cytoplasmic autoantibody (ANCA) positivity: case series

et al. 2022

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Some cases of patients with IgA nephropathy diagnosed via kidney biopsy and antineutrophil cytoplasmic antibody (ANCA) positivity have been reported. This article describes a case series comprising patients with IgA nephropathy and ANCA positivity seen at a medical center in the city of São Paulo, Brazil, from 1996 to 2016. A total of 111 patients underwent diagnostic kidney biopsies for IgA nephropathy. Five were ANCA-positive at the time of diagnosis; their mean age was 45 ± 15.3 years and they were predominantly females with a mean proteinuria of 2.2 ± 0.9 g/day and a median serum creatinine level of 2.5 (2.0 - 8,6) mg/dL; all had hematuria. Four of the five were cANCA-positive (80%); all had normal serum C3 and C4 levels; and 80% were positive for ANA. One case presented an association with infection, but no associations were found with medication. One patient had granuloma and another had a collapsing lesion. This article describes the cases of five ANCA-positive patients (with predominantly cANCA positivity) submitted to diagnostic kidney biopsies for IgA nephropathy; one patient had a collapsing lesion, but progressed well.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

IgA nephropathy in patients with serum anti-neutrophil cytoplasmic autoantibody (ANCA) positivity: case series

et al. 2022

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“…As biomarkers for IgA vasculitis, the severity of IgA vasculitis is associated with neutrophil/lymphocyte rate [ 129 ], serum neopterin and ischemia-modified albumin levels [ 130 ], skin miRNA-223-3p expression [ 131 ], and serum and urine levels of NGAL, KIM-1, and L-FABP [ 132 ]. IgA vasculitis patients sometimes exhibit ANCA positivity; however, there were no significant differences in the disease-free survival rates of chronic kidney disease and end-stage renal disease between IgA vasculitis patients with and without ANCA [ 133 ].…”

Section: Biomarkermentioning

confidence: 99%

IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

Sugino

Sawada

Nakamura

2021

IJMS

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IgA, previously called Henoch-Schönlein vasculitis, is an essential immune component that drives the host immune response to the external environment. As IgA has the unique characteristic of a flexible response to broad types of microorganisms, it sometimes causes an autoreactive response in the host human body. IgA vasculitis and related organ dysfunction are representative IgA-mediated autoimmune diseases; bacterial and viral infections often trigger IgA vasculitis. Recent drug developments and the presence of COVID-19 have revealed that these agents can also trigger IgA vasculitis. These findings provide a novel understanding of the pathogenesis of IgA vasculitis. In this review, we focus on the characteristics of IgA and symptoms of IgA vasculitis and other organ dysfunction. We also mention the therapeutic approach, biomarkers, novel triggers for IgA vasculitis, and epigenetic modifications in patients with IgA vasculitis.

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“…The association between IgAN and related ANCA-associated vasculitis is uncertain, with prevalence ranging from 1.2 to 5.8% 5 , 6 . Little is known about the clinical and prognostic importance of this combination.…”

mentioning

confidence: 99%

“…Little is known about the clinical and prognostic importance of this combination. The presence of ANCA could amplify the inflammatory reaction 5 , with a worse prognosis being described for patients with this association, if not treated with immunosuppression 6 , 7 .…”

mentioning

confidence: 99%

Crescent IgA Nephropathy and its association with anti-neutrophil cytoplasm antibody: what do we know?

2022

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Clinical significance of ANCA positivity in patients with IgA vasculitis: a retrospective monocentric study

Cited by 4 publications

References 25 publications

IgA nephropathy in patients with serum anti-neutrophil cytoplasmic autoantibody (ANCA) positivity: case series

IgA nephropathy in patients with serum anti-neutrophil cytoplasmic autoantibody (ANCA) positivity: case series

IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

Crescent IgA Nephropathy and its association with anti-neutrophil cytoplasm antibody: what do we know?

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