2022
DOI: 10.1136/bmj-2021-069761
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Abstract: Objectives To characterize the clinical severity of covid-19 associated with the alpha, delta, and omicron SARS-CoV-2 variants among adults admitted to hospital and to compare the effectiveness of mRNA vaccines to prevent hospital admissions related to each variant. Design Case-control study. Setting 21 hospitals across the United States. Participants 11 690 adul… Show more

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Cited by 433 publications
(366 citation statements)
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“…This inconsistency between our study and others may be explained by differences in the adjustment variables used, or because the larger sample size in Nyberg et al 2022 [33] allowed precise isolation of a small negative effect, with their effect estimate falling within our credible interval. Our results are consistent with studies from England, Scotland, Canada and the US suggesting that Omicron infections are less severe than infections with Delta [14,. This reduction in case severity resulted in increased numbers of patients being admitted to hospital with a coincidental positive SARS-CoV-2 test rather than due to COVID-19, but this did not seem to overly impact our estimate of the severity of the variant relative to Delta.…”
Section: Discussionsupporting
confidence: 88%
“…This inconsistency between our study and others may be explained by differences in the adjustment variables used, or because the larger sample size in Nyberg et al 2022 [33] allowed precise isolation of a small negative effect, with their effect estimate falling within our credible interval. Our results are consistent with studies from England, Scotland, Canada and the US suggesting that Omicron infections are less severe than infections with Delta [14,. This reduction in case severity resulted in increased numbers of patients being admitted to hospital with a coincidental positive SARS-CoV-2 test rather than due to COVID-19, but this did not seem to overly impact our estimate of the severity of the variant relative to Delta.…”
Section: Discussionsupporting
confidence: 88%
“…Although no such previous data are available for children, studies evaluating Covid-19 in vaccinated as compared with unvaccinated adults have shown similar disease attenuation. 10 , 32 With waning protection against infection and recurrent emergence of variants that evade immunity, ongoing monitoring is necessary to ensure that Covid-19 vaccines provide sustained attenuation of illness severity and prevent life-threatening disease.…”
Section: Discussionmentioning
confidence: 99%
“…[3] , [4] Between December 3, 2021 and April 7, 2022, there were 21 vaccine effectiveness studies that met our inclusion criteria that reported results for severe omicron disease for five vaccines ( Table 1 and Figure). [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] The majority (n=13, 62%) of studies used hospitalization with some clinical evidence of Covid-19 disease as the outcome, while six (29%) studies used hospitalization with PCR-confirmed infection without clinical criteria, and 4 (17%) used other outcomes besides hospitalization. (Two studies evaluated vaccine effectiveness for more than one severe outcome.)…”
Section: Vaccine Effectiveness Against Severe Disease Among Persons W...mentioning
confidence: 99%