Clinical risk score correlates with yield of PET scan in patients with colorectal hepatic metastases

Schussler-Fiorenza, C. Miryam; Mahvi, David M.; Niederhuber, John E.; Rikkers, Layton F.; Weber, Sharon M.

doi:10.1016/j.gassur.2003.11.009

Cited by 48 publications

(7 citation statements)

References 15 publications

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“…Inclusion of tumour-related factors in our study has shown that liver lesion factors are important determinants on their own but were not significant in multivariate analysis. Disease-free interval was shown in some previous studies to be an important factor that predicts extrahepatic disease [2]. In our study and the study by Pawlik et al [7], time interval was not a significant factor in prediction of behaviour of colorectal cancer spread.…”

Section: Discussionsupporting

confidence: 47%

“…FDG-PET scan detects extrahepatic metastases in 20% of patients with colorectal liver metastases but it is reported to have approximately 16% false negative rates [2]. Positron emission tomography with the glucose analog [ 18 F] fluoro-2-deoxy-D-glucose is a sensitive diagnostic test that detects tumours based on the increased metabolic utilisation of glucose by tumour cells.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies found some correlation between certain clinical indicators such as interval for hepatic recurrence, size of liver metastases, and CEA levels and the results of PET scan for detection of extrahepatic metastases [2]. …”

Section: Introductionmentioning

confidence: 99%

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In Colorectal Liver Metastases, the Presence of Extrahepatic Disease Correlates with the Pathology of the Primary Tumour

Abbas

Lam

2011

ISRN Oncology

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Background. FDG-PET scan detects extrahepatic metastases in 20% of patients with colorectal liver metastases but it is reported to have approximately 16% false negative rates. Patients and Methods. Patients who had PET scan for metastatic colorectal cancer at Westmead Hospital between March 2006 and March 2010 were reviewed retrospectively. The results of PET scan were correlated with tumour characteristics that were thought to affect the overall prognosis. Results. Degree of tumour differentiation and vascular invasion were significantly predictive for the presence of extrahepatic disease on PET scan, also did the level of CEA. Conclusion. The detection of extrahepatic disease in colorectal liver metastases correlates with the biologic behaviour of the primary tumour. Poorly differentiated tumours and those with lymphovascular invasion behave in aggressive fashion and likely to have wide-spread metastases. This should be considered when contemplating liver resection for colorectal metastases.

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Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

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In Colorectal Liver Metastases, the Presence of Extrahepatic Disease Correlates with the Pathology of the Primary Tumour

Abbas

Lam

2011

ISRN Oncology

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“…By means of an FDG-PET these metastases might have been detected, resulting in less disease recurrence, which might explain the trend towards a different DFS. In patients with a low CRS there is a minimal risk of occult metastatic disease and the added value of a FDG-PET is therefore limited, if not absent [22]. …”

Section: Discussionmentioning

confidence: 99%

“…Based on this series, the Fong et al [10] CRS should not be used to rationalize the use of PET/CT in those patients being investigated for potential resection of CRLM [23]. Schüssler-Fiorenza et al [22] evaluated whether the CRS correlates with the yield of FDG-PET in patients with CRLM. There was a significant association between the CRS and the yield on the FDG-PET scan and they concluded that patients with a low CRS do not benefit from a FDG-PET.…”

Section: Discussionmentioning

confidence: 99%

Preoperative FDG-PET-Scan in Patients with Resectable Colorectal Liver Metastases Does Not Improve Overall Survival: A Retrospective Analyses Stratified by Clinical Risk Score

Ayez

Ridder²,

Wiering³

et al. 2013

Dig Surg

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Background: The aim of this study was to determine whether selection with fluorine-18-deoxyglucose positron emission tomography (FDG-PET) imaging would result in an improved outcome in surgically treated patients with curative resection of colorectal liver metastases (CRLM), stratified by the clinical risk score (CRS) of Fong et al. [Ann Surg 1999;230:309-318]. Patients and Methods: Between January 2000 and December 2009, all patients who underwent resection for CRLM from two different university teaching hospitals in the Netherlands were analysed. Patients were stratified by the CRS. Results: In total 613 patients were eligible for analysis. There was no statistical difference in median disease-free survival (DFS) between patients with and without an FDG-PET scan in both low CRS [17 months (95% CI 12-22) vs. 14 months (95% CI 11-17), p = 0.332] and high CRS [14 months (95% CI 7-21) vs. 9 months (95% CI 8-10), p = 0.073]. There was no statistical difference in median overall survival (OS) between patients with and without an FDG-PET scan in both low CRS [64 months (95% CI 54-74) vs. 54 months (95% CI 42-66), p = 0.663] and high CRS [39 months (95% CI 23-55) vs. 41 months (95% CI 34-48), p = 0.903]. Conclusion: The present study could not demonstrate that patients selected by an FDG-PET scan before liver resection, and stratified by CRS, have an improvement in DFS or OS.

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Determinants of unresectability and outcome of patients with occult colorectal hepatic metastases

2005

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Clinical risk score correlates with yield of PET scan in patients with colorectal hepatic metastases

Cited by 48 publications

References 15 publications

In Colorectal Liver Metastases, the Presence of Extrahepatic Disease Correlates with the Pathology of the Primary Tumour

In Colorectal Liver Metastases, the Presence of Extrahepatic Disease Correlates with the Pathology of the Primary Tumour

Preoperative FDG-PET-Scan in Patients with Resectable Colorectal Liver Metastases Does Not Improve Overall Survival: A Retrospective Analyses Stratified by Clinical Risk Score

Determinants of unresectability and outcome of patients with occult colorectal hepatic metastases

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