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“…Most surgical meshes used currently are chemically and physically inert, nontoxic, stable and non-immunogenic. However, none of them are biologically inert, a property related to the mesh physiology and its role into the hernia repair process [ 23 ]. Implantation of any prosthetic material is quickly followed by an extraordinarily complex series of events that mark the initiation of the healing process [ 14 ].…”
Section: Current Research On Surgical Meshesmentioning
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“…Most surgical meshes used currently are chemically and physically inert, nontoxic, stable and non-immunogenic. However, none of them are biologically inert, a property related to the mesh physiology and its role into the hernia repair process [ 23 ]. Implantation of any prosthetic material is quickly followed by an extraordinarily complex series of events that mark the initiation of the healing process [ 14 ].…”
Section: Current Research On Surgical Meshesmentioning
“…Although integration and collagen deposition that result from the inflammatory response provide long-term strength, as pointed out, an aggressive integration could also be harmful to the tissue that surrounds the wound site causing a severe body reaction, inflammation, fibrosis, infection, and mesh rejection [ 23 ]. The fibrotic reaction generated by the body when a prosthetic material is introduced, such as in the case of surgical meshes for a hernia repair, is governed by the chemical nature of the material implanted and its physical characteristics.…”
Section: Current Research On Surgical Meshesmentioning
“…Synthetics have a permanent degree of inherent strength but are believed to cause more chronic pain that results from the formation of scar plate and unorganized tissue healing response. 3,4 Physicians looking for a more natural healing solution that is not a permanent implant have moved toward the use of biologics, in favor of a remodeling biomaterial that leaves the patient essentially de novo. Biologics facilitate a more natural pattern of host tissue infiltration.…”
Section: Introductionmentioning