Clinical recognition of clear-cell acanthoma (Degos')

Fine, R. M.

doi:10.1001/archderm.100.5.559

Cited by 23 publications

(27 citation statements)

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“…It often occurs as a solitary, slow‐growing nodule on the lower limbs that may persist for 2–30 years but can also be found on the trunk or face in individuals aged 50–70 years. CCA is equally common in males and females 3–6 . Although its pathogenesis remains unknown, it is considered a benign epidermal tumor 3 and speculated to have a reactive origin associated with various inflammatory conditions 7 .…”

Section: Introductionmentioning

confidence: 99%

Differences in dermoscopic findings between early and mature clear cell acanthoma

Iseki

Negishi

Nakano

et al. 2020

The Journal of Dermatology

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Clear cell acanthoma (CCA) is a rare benign epidermal tumor that is difficult to diagnose by visual inspection. Conversely, its diagnosis by dermoscopy is relatively easy owing to the characteristic serpiginous arrangement of coiled vessels, sometimes described as the "string-of-pearls" formation. However, in few published reports, the dermoscopic diagnosis of mature CCA has been reported. Here, we report the histopathological and detailed dermoscopic findings of two CCA cases. Between these, one case was of early (~6 months) CCA exhibiting the characteristic vascular string-of-pearls formation, whereas the other was of a more mature (~10 years) CCA; although the latter case showed combined thick and thin white intersecting lines with large coiled vessels and/or red clods, it had the string-of-pearls formation. Thus, regardless of CCA maturity, the string-of-pearls formation was present. We propose that the combination of combined thick and thin white intersecting lines along with the vascular string-of-pearls formation reflecting large coiled vessels and/or red clods on dermoscopy is a diagnostic clue to mature CCA.

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Section: Introductionmentioning

confidence: 99%

Differences in dermoscopic findings between early and mature clear cell acanthoma

Iseki

Negishi

Nakano

et al. 2020

The Journal of Dermatology

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“…The histochemical examination underlines the absence of phosphorylase, a constitutive enzyme, able to demote glycogen. 5 Electron microscopy studies have revealed glycogen granules. 11,12 Videodermatoscopy has been recently introduced for the diagnosis of CCA, showing homogeneous pinpointlike vascular structures, that at an higher magnification have a bush-like aspect.…”

Section: Discussionmentioning

confidence: 99%

“…1,3 Other features that may be present include a stuckon appearance and a vascular blush. 5 They usually reach a diameter of 1-4 mm until few centimetres, but a giant form has been descripted by Duperrat et al 1 Although solitary lesions are the rule, less than 30 cases of multiple CCA (from 2 up to 400 lesions) have been described in the literature to date. 6 The clinical diagnosis frequently needs to be supported using dermoscopy and, in some cases, histology is also required.…”

Section: Introductionmentioning

confidence: 99%

Multiple eruptive clear cell acanthoma

Monari

Farisoglio²,

Gualdi³

et al. 2010

J Dermatol Case Rep

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Background: Clear cell acanthoma is a rare solitary benign epidermal tumor of unknown etiology. The disease arises in the middle-age, with no sex predominance. It appears as a single reddish papule or papule-nodule and a peripheral scaling collarette is characteristic. Although solitary lesions are the rule, less than 30 cases of multiple Clear cell acanthoma have been described in the literature to date.Main observations: We report an unusual case of a healthy 74-year-old male with multiple clear cell acanthoma on the lower extremities treated successfully with cryotherapy.Conclusion: Despite significant progress in treatment of clear cell acanthoma, cryotherapy, based on liquid nitrogen, remains an important alternative in treating multiple clear cell acanthomas.

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“…CCA has been clinically described as presenting the 'stuck on' appearance of seborrheic keratosis (SK), the vascular look of a pyogenic granuloma, the scaling and exsudation of an eczema, and the advancing round border of an epithelioma. 2 Despite these characteristics, CCA is rarely clinically diagnosed prior to biopsy, since basal cell carcinoma (BCC), SK, and squamous cell carcinoma (SCC), among other conditions, are most often suspected. 3 Regarding these features and the fact that most patients present with a single lesion, CCA was formerly considered neoplastic in nature.…”

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confidence: 99%

Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases*

Veiga

Barros²,

Santos³

et al. 2013

An. Bras. Dermatol.

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Clear cell acanthoma or Degos' acanthoma is a distinct disease concerning its clinical, histopathological, and immunohistochemical features. Its pathologic nature - whether neoplastic or reactive - is still under dispute among researchers. The disease shows a chronic course and often presents with a single papulonodular lesion on the lower limbs of adults. However, cases with multiple lesions, sometimes occurring in an eruptive fashion, and with clear variation in the size and shape of the cutaneous lesions have been reported. So far, five cases in which the lesions were exclusively located in the nipple area have been reported, all in Korean women. Four of these cases mimicked eczema and one, a polypoid nodule. The aim of this article is to present clinical, histopathological, and immunohistochemical features of two additional cases in Brazilian women with similar nipple topography.

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Clinical recognition of clear-cell acanthoma (Degos')

Cited by 23 publications

References 0 publications

Differences in dermoscopic findings between early and mature clear cell acanthoma

Differences in dermoscopic findings between early and mature clear cell acanthoma

Multiple eruptive clear cell acanthoma

Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases*

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