Clinical Prognostic Factors in Malignant Parotid Gland Tumors

Lima, Roberto A.; Tavares, Marcos Roberto; Dias, Fernando Luiz; Kligerman, Jacob; Nascimento, Marilene F.; Barbosa, Mauro Marques; Cernea, Cláudio Roberto; Soares, J.; Santos, Izabella Costa; Salviano, Scheylla

doi:10.1016/j.otohns.2005.08.001

Cited by 201 publications

(202 citation statements)

References 34 publications

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“…T stage, lymph node status, age and grade of the tumors remain the most important prognostic variables for salivary gland malignancy (Spiro, 1986;Hocwald et al, 2001;Lima et al, 2005;Koul et al, 2007). Some studies have also demonstrated perineural invasion as an independent predictor of survival (Garden et al, 1997;Hocwald et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Iqbal¹,

Bhatti²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Despite being rare in incidence, malignant tumors of major salivary glands show diverse histological variation. There are limited data on major salivary gland tumor management and outcome from Pakistan. The objective of this study was to share our experience with management of malignant tumors of major salivary glands. Materials and Methods: Patients who received treatment at Shaukat Khanum Cancer Hospital and Research Center from July 2002 to June 2011 with an underlying diagnosis of a major salivary gland malignancy were included. Patient characteristics and treatment modalities were assessed. Local, regional and distant failures were determined. Disease free survival (DFS) and overall survival (OS) were calculated using Kaplan Meier curves and the Log rank test was used to determine statistical significance. Univariate and multivariate analyses were performed using Cox proportional hazard regression. Results: The parotid gland was the primary site of origin in 104 (80%) patients. Mucoepidermoid carcinoma (43%) and adenoid cystic carcinoma (24%) were the most common histological types. Surgery followed by adjuvant radiation remained the mainstay treatment modality with 81 (62%) patients. Nineteen (15%) patients were treated with surgery alone and 30 (23%) patients with locally advanced surgically inoperable tumors received radiation only. Forty one (32%) patients failed the treatment (local 12, regional 11, locoregional 5, distant 13). The expected 5 year DFS and OS were 65% and 74% respectively. On multivariate analysis, grade was the only independent predictor of DFS and nodal involvement was the only independent predictor of overall survival. Conclusions: Employing existing standards of treatment, comparable survival can be achieved in Pakistani population with major salivary gland malignancies as elsehwere in the world.

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Section: Discussionmentioning

confidence: 99%

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Iqbal¹,

Bhatti²,

Hussain³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The rate of ACC was detected as 13,6% (Yilmaz et al, 2000) and 8.7% by Turkish authors (Gunizi and Guney, 2013). Whereas this rate was detected as 14.3% in Brazil study (Lima et al, 2005).…”

Section: Discussionmentioning

confidence: 90%

“…In addition to studies demonstrating MEC as the most prevalent tumor in literature there were also investigators who found different results. The rates reporting MEC as the 1st most prevalent tumor among series were 60% (Vargas et al, 2002), 31.7% (Lima et al, 2005), 60% (Ali et al, 2010), and 20% (Kizil et al, 2013), and 43% (Iqbal et al, 2014). Some authors (Gunizi and Guney, 2013) reported the MEC frequency at an equal rate with SqCC (21.8%), while other authors reported it as the 2nd most prevalent tumor with 25% after SqCCa.…”

Section: Discussionmentioning

confidence: 96%

“…Carcinoma ex Pleomorphic Adenoma (CXPA) is distinguished from malignant mixed tumors due to its malignant epithelial component and occurs at a prevalence of 1.5-12% among salivary gland tumors (Lima et al, 2005;Ellis and Auclair, 2008). Adenocarcinoma was detected as a malignant component in all of our patients.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, authors from Brazil reported ACC as the 4th most prevalent among malignant parotid tumors (Lima et al, 2005). Yet, Turkish authors published ACC as the most prevalent among malignant tumors with 44.7% (Sungur et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Histopathological Diversity in Parotidectomy Materials in Turkish Population: Clinicopathologic Analysis and Demographic Features of 136 Cases in a Tertiary Care Hospital

Altınay¹,

Taşkın²,

Sar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Oncolytic Vaccinia Virus Therapy of Salivary Gland Carcinoma

Chernichenko¹,

Linkov²,

Li³

et al. 2013

JAMA Otolaryngol Head Neck Surg

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Objective To examine the therapeutic effects of an attenuated, replication-competent vaccinia virus (GLV-1h68) against a panel of 5 human salivary gland carcinoma cell lines. Design The susceptibility of 5 salivary gland carcinoma cell lines to infection and oncolysis by GLV-1h68 was assessed in vitro and in vivo. Results All 5 cell lines were susceptible to viral infection, transgene expression, and cytotoxic reactions. Three cell lines were exquisitely sensitive to infection by very low doses of GLV-1h68. Orthotopic parotid tumors exhibited more aggressive behavior compared with flank tumors. A single intratumoral injection of GLV-1h68 induced significant tumor regression without observed toxic effects in flank and parotid tumor models; controls demonstrated rapid tumor progression. Conclusion These promising results demonstrate significant oncolytic activity by an attenuated vaccinia virus for infecting and lysing salivary gland carcinomas, supporting future clinical trials.

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Clinical Prognostic Factors in Malignant Parotid Gland Tumors

Abstract: C.

Cited by 201 publications

References 34 publications

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Ten Year Experience with Surgery and Radiation in the Management of Malignant Major Salivary Gland Tumors

Histopathological Diversity in Parotidectomy Materials in Turkish Population: Clinicopathologic Analysis and Demographic Features of 136 Cases in a Tertiary Care Hospital

Oncolytic Vaccinia Virus Therapy of Salivary Gland Carcinoma

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